Bis(allyl) [4-(N-tert-butyloxycarbonyl)amino-1H-indol-3yl]methylphenylacetamidomalonate

Base Information

Chemical Name:Bis(allyl) [4-(N-tert-butyloxycarbonyl)amino-1H-indol-3yl]methylphenylacetamidomalonate
CAS No.:319921-01-2
Molecular Formula:C₃₁H₃₅N₃O₇
Molecular Weight:561.635
Hs Code.:

Synonyms:Bis(allyl) [4-(N-tert-butyloxycarbonyl)amino-1H-indol-3yl]methylphenylacetamidomalonate

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Chemical Property of Bis(allyl) [4-(N-tert-butyloxycarbonyl)amino-1H-indol-3yl]methylphenylacetamidomalonate

Chemical Property:

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Technology Process of Bis(allyl) [4-(N-tert-butyloxycarbonyl)amino-1H-indol-3yl]methylphenylacetamidomalonate

There total 7 articles about Bis(allyl) [4-(N-tert-butyloxycarbonyl)amino-1H-indol-3yl]methylphenylacetamidomalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 252288-56-5
Bis(allyl) phenylacetamidomalonate

: (4-tert-butoxycarbonylamino-1-triisopropylsilanyl-1H-indol-3-ylmethyl)-trimethyl-ammonium; iodide

: 319921-01-2
Bis(allyl) [4-(N-tert-butyloxycarbonyl)amino-1H-indol-3yl]methylphenylacetamidomalonate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/(SICI)1521-3773(19991004)38:19<2902::AID-ANIE2902>3.0.CO;2-2

Reference yield:

: 146886-51-3
1-(N-triisopropylsilyl-1H-indol-3-yl)-N,N-dimethylmethanamine

: 319921-01-2
Bis(allyl) [4-(N-tert-butyloxycarbonyl)amino-1H-indol-3yl]methylphenylacetamidomalonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tBuLi / diethyl ether / 1.75 h / -78 - 0 °C

1.2: 73 percent / diethyl ether / 1 h / -78 °C

2.1: 91.7 percent / tetrahydrofuran / 20 °C

3.1: MeI / dimethylformamide / 20 °C

4.1: 6.51 g / TBAF / tetrahydrofuran / 1 h / 20 °C

With tetrabutyl ammonium fluoride; tert.-butyl lithium; methyl iodide; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; 4.1: Mannich-type reaction;
DOI:10.1002/1521-3765(20001103)6:21<3943::AID-CHEM3943<3.3.CO;2-K

Reference yield:

: 146886-61-5
3-Dimethylaminomethyl-4-amino-1-triisopropylsilylindole

: 319921-01-2
Bis(allyl) [4-(N-tert-butyloxycarbonyl)amino-1H-indol-3yl]methylphenylacetamidomalonate

Guidance literature:: Multi-step reaction with 3 steps

1: 91.7 percent / tetrahydrofuran / 20 °C

2: MeI / dimethylformamide / 20 °C

3: 6.51 g / TBAF / tetrahydrofuran / 1 h / 20 °C

With tetrabutyl ammonium fluoride; methyl iodide; In tetrahydrofuran; N,N-dimethyl-formamide; 3: Mannich-type reaction;
DOI:10.1002/1521-3765(20001103)6:21<3943::AID-CHEM3943<3.3.CO;2-K