3-(4-Fluorophenyl)-6-methyl-2-(2-methyl-1-oxopropyl)-5-oxoheptanoic acid, ethyl ester

Base Information

• Chemical Name: 3-(4-Fluorophenyl)-6-methyl-2-(2-methyl-1-oxopropyl)-5-oxoheptanoic acid, ethyl ester
• CAS No.: 122252-62-4
• Molecular Formula: C₂₀H₂₇FO₄
• Molecular Weight: 350.43

Synonyms:3-(4-Fluorophenyl)-6-methyl-2-(2-methyl-1-oxopropyl)-5-oxoheptanoic acid, ethyl ester

Chemical Property of 3-(4-Fluorophenyl)-6-methyl-2-(2-methyl-1-oxopropyl)-5-oxoheptanoic acid, ethyl ester

Chemical Property:

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Technology Process of 3-(4-Fluorophenyl)-6-methyl-2-(2-methyl-1-oxopropyl)-5-oxoheptanoic acid, ethyl ester

There total 4 articles about 3-(4-Fluorophenyl)-6-methyl-2-(2-methyl-1-oxopropyl)-5-oxoheptanoic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-fluorophenyl)-4-methyl-pent-1-en-3-one (67962-05-4) + ethyl 4-methyl-3-oxo-pentanoate (7152-15-0) → 3-(4-Fluorophenyl)-6-methyl-2-(2-methyl-1-oxopropyl)-5-oxoheptanoic acid, ethyl ester (122252-62-4)

Guidance literature:

With sodium ethanolate; In ethanol; for 4.5h; Ambient temperature;

DOI:10.1021/jm00113a019

Reference yield:

3-methyl-butan-2-one (563-80-4) → 3-(4-Fluorophenyl)-6-methyl-2-(2-methyl-1-oxopropyl)-5-oxoheptanoic acid, ethyl ester (122252-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: EtONa / ethanol / 15 h / Ambient temperature

2: EtONa / ethanol / 4.5 h / Ambient temperature

With sodium ethanolate; In ethanol;

DOI:10.1021/jm00113a019

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 3-(4-Fluorophenyl)-6-methyl-2-(2-methyl-1-oxopropyl)-5-oxoheptanoic acid, ethyl ester (122252-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: EtONa / ethanol / 15 h / Ambient temperature

2: EtONa / ethanol / 4.5 h / Ambient temperature

With sodium ethanolate; In ethanol;

DOI:10.1021/jm00113a019

upstream raw materials:

1-(4-fluorophenyl)-4-methylpent-1-en-3-one

ethyl 4-methyl-3-oxo-pentanoate

1-(4-fluorophenyl)-4-methyl-pent-1-en-3-one

3-methyl-butan-2-one

Downstream raw materials:

3-{(E)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-2,6-diisopropyl-pyridine

3-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-2,6-diisopropyl-pyridine

[4-(4-Fluoro-phenyl)-2,6-diisopropyl-pyridin-3-ylmethyl]-triphenyl-phosphonium; bromide

(4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[4-(4-fluoro-phenyl)-2,6-diisopropyl-pyridin-3-yl]-vinyl}-tetrahydro-pyran-2-ol

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