N-alpha-(2-naphthylsulfonylglycyl)-1-(4-aminophenylalanine)piperidide

Base Information

• Chemical Name: N-alpha-(2-naphthylsulfonylglycyl)-1-(4-aminophenylalanine)piperidide
• CAS No.: 108460-12-4
• Molecular Formula: C₂₆H₃₀N₄O₄S
• Molecular Weight: 494.615
• Mol file: 108460-12-4.mol

Synonyms:Acetamide,N-[1-[(4-aminophenyl)methyl]-2-oxo-2-(1-piperidinyl)ethyl]-2-[(2-naphthalenylsulfonyl)amino]-,(?à)-

Chemical Property of N-alpha-(2-naphthylsulfonylglycyl)-1-(4-aminophenylalanine)piperidide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 133.47000
• Density: 1.313g/cm³
• LogP: 5.27140

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-alpha-(2-naphthylsulfonylglycyl)-1-(4-aminophenylalanine)piperidide

There total 5 articles about N-alpha-(2-naphthylsulfonylglycyl)-1-(4-aminophenylalanine)piperidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nα-(2-Naphthylsulfonylglycyl)-4-nitro-phenylalaninpiperidid (108460-09-9) → Nα-(2-Naphthylsulfonylglycyl)-4-amino-phenylalaninpiperidid (108460-12-4)

Guidance literature:

With ammonia; hydrogen; nickel; In methanol;

Reference yield:

piperidine (110-89-4) → Nα-(2-Naphthylsulfonylglycyl)-4-amino-phenylalaninpiperidid (108460-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) N-ethyl morpholine, chlorocarbon isobutylester / 1.) acetic ester, 25 min; 2.) 4 h, room temperature

2: NH₃/hydrogen / Raney-Ni / methanol

With N-ethylmorpholine;; chlorocarbon isobutylester; ammonia; hydrogen; nickel; In methanol;

Reference yield:

2-amino-3-(4-nitrophenyl)propionic acid hydrochloride (66693-69-4,147065-06-3) → Nα-(2-Naphthylsulfonylglycyl)-4-amino-phenylalaninpiperidid (108460-12-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / aqu. NaOH / ethyl acetate / 5 h

2: 1.) N-ethyl morpholine, chlorocarbon isobutylester / 1.) acetic ester, 25 min; 2.) 4 h, room temperature

3: NH₃/hydrogen / Raney-Ni / methanol

With N-ethylmorpholine;; sodium hydroxide; chlorocarbon isobutylester; ammonia; hydrogen; nickel; In methanol; ethyl acetate;

upstream raw materials:

N_α-(2-Naphthylsulfonylglycyl)-4-nitro-phenylalaninpiperidid

piperidine

2-amino-3-(4-nitrophenyl)propionic acid hydrochloride

N_α-(2-Naphthylsulfonylglycyl)-4-amino-phenylalanin