(tert-Butoxycarbonyl)-β-benzyl-L-aspartic acid 2-phenylethylamide

Base Information

• Chemical Name: (tert-Butoxycarbonyl)-β-benzyl-L-aspartic acid 2-phenylethylamide
• CAS No.: 108279-08-9
• Molecular Formula: C₂₄H₃₀N₂O₅
• Molecular Weight: 426.513
• Mol file: 108279-08-9.mol

Synonyms:(tert-Butoxycarbonyl)-β-benzyl-L-aspartic acid 2-phenylethylamide

Chemical Property of (tert-Butoxycarbonyl)-β-benzyl-L-aspartic acid 2-phenylethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (tert-Butoxycarbonyl)-β-benzyl-L-aspartic acid 2-phenylethylamide

There total 4 articles about (tert-Butoxycarbonyl)-β-benzyl-L-aspartic acid 2-phenylethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Nα-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester (13798-75-9) + phenethylamine (64-04-0) → (tert-Butoxycarbonyl)-β-benzyl-L-aspartic acid 2-phenylethylamide (108279-08-9)

Guidance literature:

In 1,2-dimethoxyethane; at 20 ℃;

DOI:10.1021/jm000937a

Reference yield: 52.0%

BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) + 2-phenylethylamine hydrochloride (156-28-5) → (tert-Butoxycarbonyl)-β-benzyl-L-aspartic acid 2-phenylethylamide (108279-08-9)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 20h; Heating;

DOI:10.1135/cccc19942511

Reference yield:

BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) → (tert-Butoxycarbonyl)-β-benzyl-L-aspartic acid 2-phenylethylamide (108279-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dicyclohexylcarbodiimide / dioxane / 20 h / Ambient temperature

2: dioxane / 20 h / Ambient temperature

With dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1248/cpb.46.1169

upstream raw materials:

BOC-L-aspartic acid 4-benzyl ester

phenethylamine

2-phenylethylamine hydrochloride

N^α-t-butoxycarbonylaspartic acid α-N-hydroxysuccinimide ester β-benzyl ester

Downstream raw materials:

H-Asp(OBzl)-NHCH₂CH₂C₆H₅*TFA

(S)-3-Amino-N-phenethyl-succinamic acid benzyl ester