2-(2-Methylpropenyl)-2-p-methoxyphenylacetic acid

Base Information

• Chemical Name: 2-(2-Methylpropenyl)-2-p-methoxyphenylacetic acid
• CAS No.: 151813-41-1
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.268
• Mol file: 151813-41-1.mol

Synonyms:2-(2-Methylpropenyl)-2-p-methoxyphenylacetic acid

Chemical Property of 2-(2-Methylpropenyl)-2-p-methoxyphenylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-Methylpropenyl)-2-p-methoxyphenylacetic acid

There total 1 articles about 2-(2-Methylpropenyl)-2-p-methoxyphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-iodo-2-methyl-2-propene (3756-30-7) + 4-Methoxyphenylacetic acid (104-01-8) → 2-(2-Methylpropenyl)-2-p-methoxyphenylacetic acid (151813-41-1)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, from -78 deg C to 0 deg C, 1.5 h, 2.) THF, from -78 deg C to RT, 1 h;

DOI:10.1021/ja00072a021

Reference yield:

2-(2-Methylpropenyl)-2-p-methoxyphenylacetic acid (151813-41-1) → 1-diazo-5-methyl-3-(p-methoxyphenyl)-5-hexen-2-one (138983-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / diethyl ether / 1 h / Ambient temperature

2: diethyl ether / 0 - 20 °C

With triethylamine; In diethyl ether;

DOI:10.1021/ja00072a021

Reference yield:

2-(2-Methylpropenyl)-2-p-methoxyphenylacetic acid (151813-41-1) → 5-methyl-3-(p-methoxyphenyl)bicyclo<3.1.0>hexan-2-one

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / diethyl ether / 1 h / Ambient temperature

2: diethyl ether / 0 - 20 °C

3: 80 percent / rhodium(II) caprolactamate / CH₂Cl₂ / 1 h / 45 °C

With dirhodium tetrakis(caprolactamate); triethylamine; In diethyl ether; dichloromethane;

DOI:10.1021/ja00072a021

upstream raw materials:

1-iodo-2-methyl-2-propene

4-Methoxyphenylacetic acid

Downstream raw materials:

4-Oxo-2-p-methoxyphenylpentanoic acid

1-diazo-5-methyl-3-(p-methoxyphenyl)-5-hexen-2-one

1-Diazo-3-p-methoxyphenyl-2,5-hexanedione

Dimethyl 5-methyl-2-oxo-3-p-methoxyphenyl-8-oxabicyclo<3.2.1>oct-6-ene-6,7-dicarboxylate