5-chloro-3-ethoxy-6-isobutyl-1-(4-methoxybenzyl)pyrazine-2(1H)-thione

Base Information

• Chemical Name: 5-chloro-3-ethoxy-6-isobutyl-1-(4-methoxybenzyl)pyrazine-2(1H)-thione
• CAS No.: 1262486-29-2
• Molecular Formula: C₁₈H₂₃ClN₂O₂S
• Molecular Weight: 366.912

Synonyms:5-chloro-3-ethoxy-6-isobutyl-1-(4-methoxybenzyl)pyrazine-2(1H)-thione

Chemical Property of 5-chloro-3-ethoxy-6-isobutyl-1-(4-methoxybenzyl)pyrazine-2(1H)-thione

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Technology Process of 5-chloro-3-ethoxy-6-isobutyl-1-(4-methoxybenzyl)pyrazine-2(1H)-thione

There total 2 articles about 5-chloro-3-ethoxy-6-isobutyl-1-(4-methoxybenzyl)pyrazine-2(1H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(4-methoxybenzyl)-5-chloro-3-ethoxy-6-isobutylpyrazin-2(1H)-one (1262486-26-9) → 5-chloro-3-ethoxy-6-isobutyl-1-(4-methoxybenzyl)pyrazine-2(1H)-thione (1262486-29-2)

Guidance literature:

With Lawessons reagent; In toluene; for 4h; Reflux;

DOI:10.1021/jo102089h

Reference yield:

1-(4-methoxybenzyl)-3,5-dichloro-6-isobutylpyrazin-2(1H)-one (849775-01-5) → 5-chloro-3-ethoxy-6-isobutyl-1-(4-methoxybenzyl)pyrazine-2(1H)-thione (1262486-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / 3 h / 0 - 30 °C

2: Lawessons reagent / toluene / 4 h / Reflux

With Lawessons reagent; sodium hydride; In toluene;

DOI:10.1021/jo102089h

Reference yield: 80.0%

5-chloro-3-ethoxy-6-isobutyl-1-(4-methoxybenzyl)pyrazine-2(1H)-thione (1262486-29-2) → 2-(4-methoxybenzylthio)-5-chloro-3-ethoxy-6-isobutylpyrazine (1262486-32-7)

Guidance literature:

With iodine; In dichloromethane; at 80 ℃; for 0.25h; Microwave irradiation;

DOI:10.1021/jo102089h

upstream raw materials:

1-(4-methoxybenzyl)-5-chloro-3-ethoxy-6-isobutylpyrazin-2(1H)-one

1-(4-methoxybenzyl)-3,5-dichloro-6-isobutylpyrazin-2(1H)-one

Downstream raw materials:

2-(4-methoxybenzylthio)-5-chloro-3-ethoxy-6-isobutylpyrazine

2-chloro-6-ethoxy-3-isobutyl-5-(3,4-dimethoxyphenyl)pyrazine

2-chloro-6-ethoxy-5-(3,4-difluorophenyl)-3-isobutylpyrazine

2-ethoxy-6-ethynyl-5-isobutyl-3-(3,4-dimethoxyphenyl)pyrazine

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