3-Phenyl-7-[(5-thiocarbamoyl-1H-indole-2-carbonyl)-amino]-heptanoic acid tert-butyl ester

Base Information

Chemical Name:3-Phenyl-7-[(5-thiocarbamoyl-1H-indole-2-carbonyl)-amino]-heptanoic acid tert-butyl ester
CAS No.:1027371-97-6
Molecular Formula:C₂₇H₃₃N₃O₃S
Molecular Weight:479.643
Hs Code.:

Synonyms:3-Phenyl-7-[(5-thiocarbamoyl-1H-indole-2-carbonyl)-amino]-heptanoic acid tert-butyl ester

Suppliers and Price of 3-Phenyl-7-[(5-thiocarbamoyl-1H-indole-2-carbonyl)-amino]-heptanoic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Phenyl-7-[(5-thiocarbamoyl-1H-indole-2-carbonyl)-amino]-heptanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-Phenyl-7-[(5-thiocarbamoyl-1H-indole-2-carbonyl)-amino]-heptanoic acid tert-butyl ester

There total 9 articles about 3-Phenyl-7-[(5-thiocarbamoyl-1H-indole-2-carbonyl)-amino]-heptanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23135-50-4
5-(N-benzyloxycarbonylamino)pentanoic acid

: 1027371-97-6
3-Phenyl-7-[(5-thiocarbamoyl-1H-indole-2-carbonyl)-amino]-heptanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 4-methylmorpholine / CH₂Cl₂ / 0.75 h / -15 °C

2: CH₂Cl₂ / 3 h / -15 °C

3: tetrahydrofuran; diethyl ether / 1 h / -78 - 0 °C

4: 1.) NaH / 1.) THF, 0 deg C, 2 h, 2.) THF, RT, 2 h

5: H₂ / 10percent Pd/C / ethyl acetate / 760 Torr

6: DMAP, iPr₂NEt, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

7: TEA, pyridine, H₂S gas / Ambient temperature

With 4-methyl-morpholine; pyridine; dmap; TEA; hydrogen sulfide; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jm970020k

Reference yield:

: 119174-36-6
benzyl [N-(5-phenyl-5-oxopentyl)amino]methanoate

: 1027371-97-6
3-Phenyl-7-[(5-thiocarbamoyl-1H-indole-2-carbonyl)-amino]-heptanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, 0 deg C, 2 h, 2.) THF, RT, 2 h

2: H₂ / 10percent Pd/C / ethyl acetate / 760 Torr

3: DMAP, iPr₂NEt, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

4: TEA, pyridine, H₂S gas / Ambient temperature

With pyridine; dmap; TEA; hydrogen sulfide; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/jm970020k

Reference yield:

: 169463-91-6
[4-(Methoxy-methyl-carbamoyl)-butyl]-carbamic acid benzyl ester

: 1027371-97-6
3-Phenyl-7-[(5-thiocarbamoyl-1H-indole-2-carbonyl)-amino]-heptanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran; diethyl ether / 1 h / -78 - 0 °C

2: 1.) NaH / 1.) THF, 0 deg C, 2 h, 2.) THF, RT, 2 h

3: H₂ / 10percent Pd/C / ethyl acetate / 760 Torr

4: DMAP, iPr₂NEt, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

5: TEA, pyridine, H₂S gas / Ambient temperature

With pyridine; dmap; TEA; hydrogen sulfide; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jm970020k