tert-butyl 2-(5-(tert-butoxycarbonyloxy)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl(2-(N-cycloheptyl-3-(3-(1-methyl-1H-1,2,3-triazol-4-yl)phenethoxy)propanamido)ethyl)carbamate

Base Information

Chemical Name:tert-butyl 2-(5-(tert-butoxycarbonyloxy)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl(2-(N-cycloheptyl-3-(3-(1-methyl-1H-1,2,3-triazol-4-yl)phenethoxy)propanamido)ethyl)carbamate
CAS No.:1201640-67-6
Molecular Formula:C₄₃H₆₀N₆O₉
Molecular Weight:804.984
Hs Code.:

tert-butyl 2-(5-(tert-butoxycarbonyloxy)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl(2-(N-cycloheptyl-3-(3-(1-methyl-1H-1,2,3-triazol-4-yl)phenethoxy)propanamido)ethyl)carbamate

Synonyms:tert-butyl 2-(5-(tert-butoxycarbonyloxy)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl(2-(N-cycloheptyl-3-(3-(1-methyl-1H-1,2,3-triazol-4-yl)phenethoxy)propanamido)ethyl)carbamate

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Chemical Property of tert-butyl 2-(5-(tert-butoxycarbonyloxy)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl(2-(N-cycloheptyl-3-(3-(1-methyl-1H-1,2,3-triazol-4-yl)phenethoxy)propanamido)ethyl)carbamate

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Technology Process of tert-butyl 2-(5-(tert-butoxycarbonyloxy)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl(2-(N-cycloheptyl-3-(3-(1-methyl-1H-1,2,3-triazol-4-yl)phenethoxy)propanamido)ethyl)carbamate

There total 16 articles about tert-butyl 2-(5-(tert-butoxycarbonyloxy)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl(2-(N-cycloheptyl-3-(3-(1-methyl-1H-1,2,3-triazol-4-yl)phenethoxy)propanamido)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1201640-66-5
N-cycloheptyl-N-(2,2-dimethoxyethyl)-3-(3-(1-methyl-1H-1,2,3-triazol-4-yl)phenethoxy)propanamide

: 8-(2-aminoethyl)-5-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride

: 1201640-67-6
tert-butyl 2-(5-(tert-butoxycarbonyloxy)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl(2-(N-cycloheptyl-3-(3-(1-methyl-1H-1,2,3-triazol-4-yl)phenethoxy)propanamido)ethyl)carbamate

Guidance literature:: N-cycloheptyl-N-(2,2-dimethoxyethyl)-3-(3-(1-methyl-1H-1,2,3-triazol-4-yl)phenethoxy)propanamide; With toluene-4-sulfonic acid; In dichloromethane; at 25 ℃; for 0.75h;

8-(2-aminoethyl)-5-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride; With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; for 0.0833333h;

di-tert-butyl dicarbonate;

Reference yield:

: 871101-87-0
1‐(3‐amino‐4‐(benzyloxy)‐2‐hydroxyphenyl)ethanone

: 1201640-67-6
tert-butyl 2-(5-(tert-butoxycarbonyloxy)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl(2-(N-cycloheptyl-3-(3-(1-methyl-1H-1,2,3-triazol-4-yl)phenethoxy)propanamido)ethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide

1.2: 20 h / 100 °C

2.1: N,N,N-trimethylbenzenemethanaminium dichloroiodate / ethanol / 1 h / Reflux

3.1: sodium azide / N,N-dimethyl-formamide / 2 h

4.1: hydrogenchloride; hydrogen; acetic acid / palladium 10% on activated carbon / water / 70.3 h / 25 - 40 °C / 3525.35 Torr

5.1: toluene-4-sulfonic acid / dichloromethane / 0.75 h / 25 °C

5.2: 0.08 h

With hydrogenchloride; sodium azide; hydrogen; sodium hydrogencarbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; toluene-4-sulfonic acid; acetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1035229-31-2
1-(4-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone

: 1201640-67-6
tert-butyl 2-(5-(tert-butoxycarbonyloxy)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl(2-(N-cycloheptyl-3-(3-(1-methyl-1H-1,2,3-triazol-4-yl)phenethoxy)propanamido)ethyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; zinc / 20 - 40 °C / Cooling with ice

2.1: sodium hydrogencarbonate / N,N-dimethyl-formamide

2.2: 20 h / 100 °C

3.1: N,N,N-trimethylbenzenemethanaminium dichloroiodate / ethanol / 1 h / Reflux

4.1: sodium azide / N,N-dimethyl-formamide / 2 h

5.1: hydrogenchloride; hydrogen; acetic acid / palladium 10% on activated carbon / water / 70.3 h / 25 - 40 °C / 3525.35 Torr

6.1: toluene-4-sulfonic acid / dichloromethane / 0.75 h / 25 °C

6.2: 0.08 h

With hydrogenchloride; sodium azide; hydrogen; sodium hydrogencarbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; toluene-4-sulfonic acid; acetic acid; zinc; palladium 10% on activated carbon; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;