R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-benzyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine

Base Information

• Chemical Name: R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-benzyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine
• CAS No.: 119835-83-5
• Molecular Formula: C₃₈H₃₅N₃O₇
• Molecular Weight: 645.712
• Mol file: 119835-83-5.mol

Synonyms:R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-benzyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine

Chemical Property of R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-benzyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-benzyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine

There total 4 articles about R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-benzyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-((S)-3-Benzyloxy-2-chloromethoxy-propyl)-isoindole-1,3-dione (119835-80-2) + 2,4-dimethoxy-5-(3'-benzyloxybenzyl)pyrimidine (82857-72-5) → R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-benzyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine (119835-83-5)

Guidance literature:

With potassium carbonate; In dichloromethane; for 48h; Ambient temperature;

DOI:10.1002/jhet.5570250561

Reference yield:

(R)-3-(benzyloxy)-2-hydroxypropyl 4-methylbenzene sulfonate (23214-66-6) → R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-benzyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine (119835-83-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylformamide / 30 h / 120 °C

2: HCl (g) / CH₂Cl₂ / 3 h / 0 °C

3: 72 percent / K₂CO₃ (s) / CH₂Cl₂ / 48 h / Ambient temperature

With hydrogenchloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570250561

Reference yield:

potassium phtalimide (1074-82-4) → R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-benzyloxyethoxy)methyl>-2-oxo-4-methoxypyrimidine (119835-83-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylformamide / 30 h / 120 °C

2: HCl (g) / CH₂Cl₂ / 3 h / 0 °C

3: 72 percent / K₂CO₃ (s) / CH₂Cl₂ / 48 h / Ambient temperature

With hydrogenchloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570250561

upstream raw materials:

2-((S)-3-Benzyloxy-2-chloromethoxy-propyl)-isoindole-1,3-dione

2,4-dimethoxy-5-(3'-benzyloxybenzyl)pyrimidine

(R)-3-(benzyloxy)-2-hydroxypropyl 4-methylbenzene sulfonate

potassium phtalimide

Downstream raw materials:

R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>uracil

R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine

R-(+)-5-(3'-benzyloxybenzyl)-1-<(1'-aminomethyl-2'-hydroxyethoxy)methyl>uracil

R-(+)-5-(3'-hydroxybenzyl)-1-<(1'-phtalimidomethyl-2'-hydroxyethoxy)methyl>-2-oxo-4-methoxypyrimidine