2-(3,5-bis-trifluoromethylphenyl)-N-[1-(2,2-difluoroethyl)-4-(4-fluoro-2-methylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methylisobutyramide

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Chemical Name:2-(3,5-bis-trifluoromethylphenyl)-N-[1-(2,2-difluoroethyl)-4-(4-fluoro-2-methylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methylisobutyramide
CAS No.:1340591-78-7
Molecular Formula:C₂₈H₂₃F₉N₄O
Molecular Weight:602.502
Hs Code.:

Synonyms:2-(3,5-bis-trifluoromethylphenyl)-N-[1-(2,2-difluoroethyl)-4-(4-fluoro-2-methylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methylisobutyramide

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Chemical Property of 2-(3,5-bis-trifluoromethylphenyl)-N-[1-(2,2-difluoroethyl)-4-(4-fluoro-2-methylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methylisobutyramide

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Technology Process of 2-(3,5-bis-trifluoromethylphenyl)-N-[1-(2,2-difluoroethyl)-4-(4-fluoro-2-methylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methylisobutyramide

There total 8 articles about 2-(3,5-bis-trifluoromethylphenyl)-N-[1-(2,2-difluoroethyl)-4-(4-fluoro-2-methylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methylisobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1340592-00-8
2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-isobutyramide

: 74427-22-8
2,2-difluoroethyl triflate

: 1340591-78-7
2-(3,5-bis-trifluoromethylphenyl)-N-[1-(2,2-difluoroethyl)-4-(4-fluoro-2-methylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methylisobutyramide

Guidance literature:: 2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-isobutyramide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

2,2-difluoroethyl triflate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1340592-22-4
[1-benzyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-methyl-amine

: 1340591-78-7
2-(3,5-bis-trifluoromethylphenyl)-N-[1-(2,2-difluoroethyl)-4-(4-fluoro-2-methylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methylisobutyramide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 40 °C

2.1: hydrogenchloride; hydrogen / palladium on activated charcoal / water; methanol / 20 h / 60 °C / 7500.75 Torr

2.2: pH 8

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 0 - 20 °C

With hydrogenchloride; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1340591-83-4
N-[1-benzyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-isobutyramide

: 1340591-78-7
2-(3,5-bis-trifluoromethylphenyl)-N-[1-(2,2-difluoroethyl)-4-(4-fluoro-2-methylphenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methylisobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; hydrogen / palladium on activated charcoal / water; methanol / 20 h / 60 °C / 7500.75 Torr

1.2: pH 8

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 0 - 20 °C

With hydrogenchloride; hydrogen; sodium hydride; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide;