2-fluoro-5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-benzaldehyde

Base Information

Chemical Name:2-fluoro-5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-benzaldehyde
CAS No.:1310689-18-9
Molecular Formula:C₂₂H₂₄FN₃O₂
Molecular Weight:381.45
Hs Code.:

Synonyms:2-fluoro-5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-benzaldehyde

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Chemical Property of 2-fluoro-5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-benzaldehyde

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Technology Process of 2-fluoro-5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-benzaldehyde

There total 4 articles about 2-fluoro-5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: C₁₃H₁₆FNO

: 14625-40-2
2-(chloromethyl)-5-methoxy-1H-benzimidazole

: 1310689-18-9
2-fluoro-5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-benzaldehyde

Guidance literature:: With sodium carbonate; In acetonitrile; for 15h; Reflux;
DOI:10.1016/j.ejmech.2011.03.013

Reference yield:

: 1310689-14-5
tert-butyl 1-[4-(3-formyl-4-fluorobenzyl)piperidin-1-yl]carboxylate

: 1310689-18-9
2-fluoro-5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / water; ethyl acetate / 12 h / 20 °C

1.2: pH 11

2.1: sodium carbonate / acetonitrile / 15 h / Reflux

With hydrogenchloride; sodium carbonate; In water; ethyl acetate; acetonitrile;
DOI:10.1016/j.ejmech.2011.03.013

Reference yield:

: 159635-49-1
tert-butyl 4-methylidenepiperidine-1-carboxylate

: 1310689-18-9
2-fluoro-5-[1-(5-methoxybenzimidazol-2-ylmethyl)piperidin-4-ylmethyl]-benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 1 h / Reflux

1.2: 3 h / 65 °C

2.1: hydrogenchloride / water; ethyl acetate / 12 h / 20 °C

2.2: pH 11

3.1: sodium carbonate / acetonitrile / 15 h / Reflux

With hydrogenchloride; sodium carbonate; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; water; ethyl acetate; acetonitrile; 1.2: Suzuki coupling;
DOI:10.1016/j.ejmech.2011.03.013