1-(4'-{4-[(R)-1-(2-chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

Base Information

Chemical Name:1-(4'-{4-[(R)-1-(2-chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid
CAS No.:1257213-60-7
Molecular Formula:C₂₉H₂₅ClN₂O₅
Molecular Weight:516.981
Hs Code.:

Synonyms:1-(4'-{4-[(R)-1-(2-chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

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Chemical Property of 1-(4'-{4-[(R)-1-(2-chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

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Technology Process of 1-(4'-{4-[(R)-1-(2-chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

There total 14 articles about 1-(4'-{4-[(R)-1-(2-chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1423689-63-7
C₃₀H₂₇ClN₂O₅

: 1257213-60-7
1-(4'-{4-[(R)-1-(2-chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

Guidance literature:: C₃₀H₂₇ClN₂O₅; With lithium hydroxide monohydrate; water; In methanol; at 20 ℃;

With hydrogenchloride; In water; pH=4 - 5;

Reference yield:

: 91182-60-4
5-(4-bromophenyl)-3-methylisoxazole-4-carboxylic acid

: 1257213-60-7
1-(4'-{4-[(R)-1-(2-chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 90 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 90 °C / Inert atmosphere

3.1: water; lithium hydroxide monohydrate / methanol / 20 °C

3.2: pH 4 - 5

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; sodium carbonate; triethylamine; In methanol; 1,2-dimethoxyethane; water; toluene;

Reference yield:

: 1228689-61-9
methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate

: 1257213-60-7
1-(4'-{4-[(R)-1-(2-chloro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide; water / methanol / 1 h / pH 2 / Inert atmosphere

1.2: pH 2

2.1: diphenyl phosphoryl azide; triethylamine / toluene / 3 h / 90 °C

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 90 °C / Inert atmosphere

4.1: water; lithium hydroxide monohydrate / methanol / 20 °C

4.2: pH 4 - 5

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; diphenyl phosphoryl azide; water; sodium carbonate; triethylamine; lithium hydroxide; In methanol; 1,2-dimethoxyethane; water; toluene;