cornigerine

Base Information

Chemical Name:cornigerine
CAS No.:6877-25-4
Molecular Formula:C21H21 N O6
Molecular Weight:383.39
Hs Code.:
NSC Number:358825
DSSTox Substance ID:DTXSID70875308
Wikidata:Q82856674
Mol file:6877-25-4.mol

Synonyms:Acetamide,N-(4,6,7,8-tetrahydro-3,13-dimethoxy-4-oxoheptaleno[1,2-f][1,3]benzodioxol-6-yl)-,(S)-; Cornigerine (7CI,8CI); Heptaleno[1,2-f][1,3]benzodioxole, acetamidederiv.; (-)-Cornigerine; NSC 358825

Suppliers and Price of cornigerine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
CORNIGERINE 95.00%
5MG
$ 503.54

Total 6 raw suppliers

Chemical Property of cornigerine

Chemical Property:

Boiling Point:744.5oC at 760 mmHg
Flash Point:404.1oC
PSA：83.09000
Density:1.35g/cm3
LogP:2.97400
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:383.13688739
Heavy Atom Count:28
Complexity:754

Purity/Quality:

99%, ^*data from raw suppliers

CORNIGERINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1CCC2=CC3=C(C(=C2C4=CC=C(C(=O)C=C14)OC)OC)OCO3

Technology Process of cornigerine

There total 2 articles about cornigerine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 74-97-5
chlorobromomethane

: 57866-21-4
2,3-didemethylcolchicine

: 6877-25-4
cornigerine

Guidance literature:: With potassium carbonate; In acetonitrile; at 60 ℃; for 21h;

Reference yield:

: 7336-33-6
3-demethylcolchicine

: 6877-25-4
cornigerine

Guidance literature:: Multi-step reaction with 2 steps

1: conc. H₂SO₄ / 2.5 h / 85 - 90 °C

2: K₂CO₃ / various solvent(s) / 2.5 h / 70 °C

With sulfuric acid; potassium carbonate; In various solvent(s);
DOI:10.1021/jo00331a021