25-{3,5-dimethyl-4-[25-(4-(2-triisopropylsilylethynyl)phenyl)pentacos-24-yn-1-yloxy]-1-iodophenyl}pentacos-24-yn-1-ol

Base Information

Chemical Name:25-{3,5-dimethyl-4-[25-(4-(2-triisopropylsilylethynyl)phenyl)pentacos-24-yn-1-yloxy]-1-iodophenyl}pentacos-24-yn-1-ol
CAS No.:499138-76-0
Molecular Formula:C₇₅H₁₂₆O₂Si
Molecular Weight:1087.91
Hs Code.:

Synonyms:25-{3,5-dimethyl-4-[25-(4-(2-triisopropylsilylethynyl)phenyl)pentacos-24-yn-1-yloxy]-1-iodophenyl}pentacos-24-yn-1-ol

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Chemical Property of 25-{3,5-dimethyl-4-[25-(4-(2-triisopropylsilylethynyl)phenyl)pentacos-24-yn-1-yloxy]-1-iodophenyl}pentacos-24-yn-1-ol

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Technology Process of 25-{3,5-dimethyl-4-[25-(4-(2-triisopropylsilylethynyl)phenyl)pentacos-24-yn-1-yloxy]-1-iodophenyl}pentacos-24-yn-1-ol

There total 10 articles about 25-{3,5-dimethyl-4-[25-(4-(2-triisopropylsilylethynyl)phenyl)pentacos-24-yn-1-yloxy]-1-iodophenyl}pentacos-24-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 120706-55-0
24-pentacosayn-1-ol

: 499138-74-8
3,5-dimethyl-4-{25-[4-(2-triisopropylsilylethynyl)phenyl]pentacos-24-yn-1-yloxy}-1-iodobenzene

: 499138-76-0
25-{3,5-dimethyl-4-[25-(4-(2-triisopropylsilylethynyl)phenyl)pentacos-24-yn-1-yloxy]-1-iodophenyl}pentacos-24-yn-1-ol

Guidance literature:: With piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; at 50 ℃; for 19h;
DOI:10.1002/1521-3765(20021115)8:22<5094::AID-CHEM5094>3.0.CO;2-6

Reference yield:

: 6938-66-5
1-Bromodocosane

: 499138-76-0
25-{3,5-dimethyl-4-[25-(4-(2-triisopropylsilylethynyl)phenyl)pentacos-24-yn-1-yloxy]-1-iodophenyl}pentacos-24-yn-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -73 °C

1.2: N,N'-dimethyl-N,N'-propylene urea / tetrahydrofuran; hexane / 17.5 h / 20 °C

2.1: 40.3 g / TsOH*H₂O / dioxane; methanol / 4.5 h / 20 °C

3.1: 75 percent / Li; 1,3-diaminopropane; KO-t-Bu / 24 h / 40 - 45 °C

4.1: 66 percent / piperidine; CuI / [Pd(PPh₃)2Cl₂] / 21 h / 20 °C

5.1: 82 percent / diisopropyl azodicarboxylate; PPh₃ / tetrahydrofuran / 27 h / 20 °C

6.1: 68 percent / CuI; piperidine / [Pd(PPh₃)2Cl₂] / 19 h / 50 °C

With piperidine; copper(l) iodide; n-butyllithium; di-isopropyl azodicarboxylate; potassium tert-butylate; lithium; toluene-4-sulfonic acid; Trimethylenediamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; 5.1: Mitsunobu reaction;
DOI:10.1002/1521-3765(20021115)8:22<5094::AID-CHEM5094>3.0.CO;2-6

Reference yield:

: 499138-63-5
pentacos-2-yn-1-ol

: 499138-76-0
25-{3,5-dimethyl-4-[25-(4-(2-triisopropylsilylethynyl)phenyl)pentacos-24-yn-1-yloxy]-1-iodophenyl}pentacos-24-yn-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / Li; 1,3-diaminopropane; KO-t-Bu / 24 h / 40 - 45 °C

2: 66 percent / piperidine; CuI / [Pd(PPh₃)2Cl₂] / 21 h / 20 °C

3: 82 percent / diisopropyl azodicarboxylate; PPh₃ / tetrahydrofuran / 27 h / 20 °C

4: 68 percent / CuI; piperidine / [Pd(PPh₃)2Cl₂] / 19 h / 50 °C

With piperidine; copper(l) iodide; di-isopropyl azodicarboxylate; potassium tert-butylate; lithium; Trimethylenediamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 3: Mitsunobu reaction;
DOI:10.1002/1521-3765(20021115)8:22<5094::AID-CHEM5094>3.0.CO;2-6