benzyl-[7-(2-{5-[2-(7-benzyloxynaphthalen-2-yloxy)-ethy]-2,2-dimethyl-[1,3]-dioxolan-4-yl}-ethoxy)-naphthalen-2-yl]-amine

Base Information

Chemical Name:benzyl-[7-(2-{5-[2-(7-benzyloxynaphthalen-2-yloxy)-ethy]-2,2-dimethyl-[1,3]-dioxolan-4-yl}-ethoxy)-naphthalen-2-yl]-amine
CAS No.:710328-84-0
Molecular Formula:C₄₃H₄₃NO₅
Molecular Weight:653.818
Hs Code.:

Synonyms:benzyl-[7-(2-{5-[2-(7-benzyloxynaphthalen-2-yloxy)-ethy]-2,2-dimethyl-[1,3]-dioxolan-4-yl}-ethoxy)-naphthalen-2-yl]-amine

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Chemical Property of benzyl-[7-(2-{5-[2-(7-benzyloxynaphthalen-2-yloxy)-ethy]-2,2-dimethyl-[1,3]-dioxolan-4-yl}-ethoxy)-naphthalen-2-yl]-amine

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Technology Process of benzyl-[7-(2-{5-[2-(7-benzyloxynaphthalen-2-yloxy)-ethy]-2,2-dimethyl-[1,3]-dioxolan-4-yl}-ethoxy)-naphthalen-2-yl]-amine

There total 10 articles about benzyl-[7-(2-{5-[2-(7-benzyloxynaphthalen-2-yloxy)-ethy]-2,2-dimethyl-[1,3]-dioxolan-4-yl}-ethoxy)-naphthalen-2-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 710328-80-6
7-benzylamino-2-naphthol

: 710328-82-8
toluene-4-sulfonic acid 2-{5-[2-(7-benzyloxynaphthalen-2-yloxy)-ethy]-2,2-dimethyl-[1,3]-dioxolan-4-yl} ethyl ester

: 710328-84-0
benzyl-[7-(2-{5-[2-(7-benzyloxynaphthalen-2-yloxy)-ethy]-2,2-dimethyl-[1,3]-dioxolan-4-yl}-ethoxy)-naphthalen-2-yl]-amine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 24h;
DOI:10.1016/j.tet.2004.02.065

Reference yield:

: 710328-81-7
2-(1,1,2,2,3,3,4,4-nonafluorobutane-1-oxysulfonyl)-7-(tert-butyldimethylsilyl)-naphthalene

: 710328-84-0
benzyl-[7-(2-{5-[2-(7-benzyloxynaphthalen-2-yloxy)-ethy]-2,2-dimethyl-[1,3]-dioxolan-4-yl}-ethoxy)-naphthalen-2-yl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: NaO-t-Bu; racemic BINAP / Pd(dba)2 / toluene / 95 - 100 °C

2: 5.55 g / TBAF / tetrahydrofuran

3: 95 percent / Cs₂CO₃ / dimethylformamide / 24 h / 65 °C

With tetrabutyl ammonium fluoride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2004.02.065

Reference yield:

: 29311-53-3
(E)-3-hexene-1,6-dioic acid

: 710328-84-0
benzyl-[7-(2-{5-[2-(7-benzyloxynaphthalen-2-yloxy)-ethy]-2,2-dimethyl-[1,3]-dioxolan-4-yl}-ethoxy)-naphthalen-2-yl]-amine

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / acetyl chloride / Heating

2: 64 percent / AD-mix-β; methanesulfonamide; NaHCO3 / H2O; 2-methyl-propan-2-ol / 0 °C

3: 9.8 g / TsOH*H₂O; molecular sieves

4: lithium aluminum hydride / tetrahydrofuran / Heating

5: 50 percent / DMAP; Et₃N / CH₂Cl₂ / 0 °C

6: Cs₂CO₃ / dimethylformamide / 65 °C

7: 425.4 mg / DMAP; Et₃N / CH₂Cl₂ / 4 h / 0 °C

8: 95 percent / Cs₂CO₃ / dimethylformamide / 24 h / 65 °C

With dmap; lithium aluminium tetrahydride; molecular sieve; methanesulfonamide; AD-mix-β; sodium hydrogencarbonate; caesium carbonate; toluene-4-sulfonic acid; triethylamine; acetyl chloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 2: Sharpless asymmetric dihydroxylation;
DOI:10.1016/j.tet.2004.02.065