(E)-3-{(S)-2-[(R)-3-(1H-Indol-3-yl)-2-methyl-2-((1R,2R)-2-methyl-cyclohexyloxycarbonylamino)-propionylamino]-3-phenyl-propylcarbamoyl}-acrylic acid methyl ester

Base Information

Chemical Name:(E)-3-{(S)-2-[(R)-3-(1H-Indol-3-yl)-2-methyl-2-((1R,2R)-2-methyl-cyclohexyloxycarbonylamino)-propionylamino]-3-phenyl-propylcarbamoyl}-acrylic acid methyl ester
CAS No.:146566-58-7
Molecular Formula:C₃₄H₄₂N₄O₆
Molecular Weight:602.731
Hs Code.:

(E)-3-{(S)-2-[(R)-3-(1H-Indol-3-yl)-2-methyl-2-((1R,2R)-2-methyl-cyclohexyloxycarbonylamino)-propionylamino]-3-phenyl-propylcarbamoyl}-acrylic acid methyl ester

Synonyms:(E)-3-{(S)-2-[(R)-3-(1H-Indol-3-yl)-2-methyl-2-((1R,2R)-2-methyl-cyclohexyloxycarbonylamino)-propionylamino]-3-phenyl-propylcarbamoyl}-acrylic acid methyl ester

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Chemical Property of (E)-3-{(S)-2-[(R)-3-(1H-Indol-3-yl)-2-methyl-2-((1R,2R)-2-methyl-cyclohexyloxycarbonylamino)-propionylamino]-3-phenyl-propylcarbamoyl}-acrylic acid methyl ester

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Technology Process of (E)-3-{(S)-2-[(R)-3-(1H-Indol-3-yl)-2-methyl-2-((1R,2R)-2-methyl-cyclohexyloxycarbonylamino)-propionylamino]-3-phenyl-propylcarbamoyl}-acrylic acid methyl ester

There total 6 articles about (E)-3-{(S)-2-[(R)-3-(1H-Indol-3-yl)-2-methyl-2-((1R,2R)-2-methyl-cyclohexyloxycarbonylamino)-propionylamino]-3-phenyl-propylcarbamoyl}-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: methyl pentafluorophenyl fumarate

: 146566-57-6
[(R)-1-((S)-1-Aminomethyl-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid (1R,2R)-2-methyl-cyclohexyl ester

: 146566-58-7
(E)-3-{(S)-2-[(R)-3-(1H-Indol-3-yl)-2-methyl-2-((1R,2R)-2-methyl-cyclohexyloxycarbonylamino)-propionylamino]-3-phenyl-propylcarbamoyl}-acrylic acid methyl ester

Guidance literature:: In ethyl acetate; for 16h; Ambient temperature;
DOI:10.1021/jm00057a005

Reference yield:

: 19043-03-9
(1R,2R)-(-)-trans-2-methylcyclohexanol

: 146566-58-7
(E)-3-{(S)-2-[(R)-3-(1H-Indol-3-yl)-2-methyl-2-((1R,2R)-2-methyl-cyclohexyloxycarbonylamino)-propionylamino]-3-phenyl-propylcarbamoyl}-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) pyridine, 2.) Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) THF, RT, 3 h

2: 97 percent / aq. LiOH / dioxane / 36 h / Ambient temperature

3: 1.) pentafluorophenyl, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 4 h, 2.) EtOAc, RT, 18 h

4: 100 percent / 1percent ethanolic AcOH, H₂ / 10percent Pd/C / 2 h / 30 °C / 2585.7 Torr

5: 82 percent / ethyl acetate / 16 h / Ambient temperature

With pyridine; lithium hydroxide; Pentafluorobenzene; hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethyl acetate;
DOI:10.1021/jm00057a005

Reference yield:

: 96551-27-8
α-methyl-(R)-tryptophan methyl ester

: 146566-58-7
(E)-3-{(S)-2-[(R)-3-(1H-Indol-3-yl)-2-methyl-2-((1R,2R)-2-methyl-cyclohexyloxycarbonylamino)-propionylamino]-3-phenyl-propylcarbamoyl}-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) pyridine, 2.) Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) THF, RT, 3 h

2: 97 percent / aq. LiOH / dioxane / 36 h / Ambient temperature

3: 1.) pentafluorophenyl, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 4 h, 2.) EtOAc, RT, 18 h

4: 100 percent / 1percent ethanolic AcOH, H₂ / 10percent Pd/C / 2 h / 30 °C / 2585.7 Torr

5: 82 percent / ethyl acetate / 16 h / Ambient temperature

With pyridine; lithium hydroxide; Pentafluorobenzene; hydrogen; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethyl acetate;
DOI:10.1021/jm00057a005