4-((S)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-4-phosphonobutyryl)piperazine-1-carboxylic acid butyl ester

Base Information

Chemical Name:4-((S)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-4-phosphonobutyryl)piperazine-1-carboxylic acid butyl ester
CAS No.:1159500-37-4
Molecular Formula:C₂₉H₄₁N₆O₈P
Molecular Weight:632.654
Hs Code.:

Synonyms:4-((S)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-4-phosphonobutyryl)piperazine-1-carboxylic acid butyl ester

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Chemical Property of 4-((S)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-4-phosphonobutyryl)piperazine-1-carboxylic acid butyl ester

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Technology Process of 4-((S)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-4-phosphonobutyryl)piperazine-1-carboxylic acid butyl ester

There total 2 articles about 4-((S)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-4-phosphonobutyryl)piperazine-1-carboxylic acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1159501-85-5
4-((S)-4-diethoxyphosphoryl-2-((6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl)amino)butyryl)piperazine-1-carboxylic acid butyl ester

: 1159500-37-4
4-((S)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-4-phosphonobutyryl)piperazine-1-carboxylic acid butyl ester

Guidance literature:: 4-((S)-4-diethoxyphosphoryl-2-((6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl)amino)butyryl)piperazine-1-carboxylic acid butyl ester; With trimethylsilyl bromide; In acetonitrile; at 0 - 20 ℃;

With water; In dichloromethane; acetonitrile; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b00933

Reference yield:

: 1159500-37-4
4-((S)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-4-phosphonobutyryl)piperazine-1-carboxylic acid butyl ester

Guidance literature:

Reference yield:

: 1159500-37-4
4-((S)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-4-phosphonobutyryl)piperazine-1-carboxylic acid butyl ester

: 623-33-6
glycine ethyl ester hydrochloride

: 1159501-10-6
N,N'-bis(ethoxycarbonylmethyl)-3-((S)-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl)amino)-4-oxo-4-(4-butoxycarbonylpiperazin-1-yl)butylphosphonic acid diamide

Guidance literature:: 4-((S)-2-{[6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-4-phosphonobutyryl)piperazine-1-carboxylic acid butyl ester; glycine ethyl ester hydrochloride; With triethylamine; In pyridine; at 60 ℃; for 0.0833333h;

With 2,2'-dipyridyldisulphide; triphenylphosphine; In pyridine; at 60 ℃;