5'-O-[3-(2-hydroxy-2-methylpropyl)sulfonylmethyl-4',4''-dimethoxytrityl]thymidine

Base Information

Chemical Name:5'-O-[3-(2-hydroxy-2-methylpropyl)sulfonylmethyl-4',4''-dimethoxytrityl]thymidine
CAS No.:541548-49-6
Molecular Formula:C₃₆H₄₂N₂O₁₀S
Molecular Weight:694.803
Hs Code.:

Synonyms:5'-O-[3-(2-hydroxy-2-methylpropyl)sulfonylmethyl-4',4''-dimethoxytrityl]thymidine

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Chemical Property of 5'-O-[3-(2-hydroxy-2-methylpropyl)sulfonylmethyl-4',4''-dimethoxytrityl]thymidine

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Technology Process of 5'-O-[3-(2-hydroxy-2-methylpropyl)sulfonylmethyl-4',4''-dimethoxytrityl]thymidine

There total 12 articles about 5'-O-[3-(2-hydroxy-2-methylpropyl)sulfonylmethyl-4',4''-dimethoxytrityl]thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 541541-15-5
5'-O-[3-[2-(tert-butyldimethylsilyloxy)-2-methylpropyl]sulfonylmethyl-4',4''-dimethoxytrityl]thymidine

: 541548-49-6
5'-O-[3-(2-hydroxy-2-methylpropyl)sulfonylmethyl-4',4''-dimethoxytrityl]thymidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 10h;

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 541548-49-6
5'-O-[3-(2-hydroxy-2-methylpropyl)sulfonylmethyl-4',4''-dimethoxytrityl]thymidine

Guidance literature:: Multi-step reaction with 11 steps

1.1: magnesium / tetrahydrofuran / 1 h / 20 °C

1.2: 81 percent / tetrahydrofuran / 1 h / 0 - 20 °C

2.1: acetyl chloride / 1 h / Heating

3.1: 43.2 g / pyridine / 0 °C

4.1: 77 percent Spectr_. / N-bromosuccinimide; N,N'-azobisisobutyronitrile / CCl₄ / 0.33 h / Heating

5.1: 32 g / N-ethyldiisopropylamine / dimethylformamide / 3 h / 20 °C

6.1: 74 percent / m-chloroperbenzoic acid; sodium bicarbonate / CH₂Cl₂ / 0.17 h / 0 °C

7.1: 90 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 20 °C

8.1: 96 percent / aqueous acetic acid / 1 h / 20 °C

9.1: 98 percent / acetyl chloride / toluene / 1 h / Heating

10.1: 95 percent / pyridine / 3 h / 20 °C

11.1: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 10 h / 20 °C

With pyridine; 2,6-dimethylpyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; sodium hydrogencarbonate; magnesium; acetic acid; N-ethyl-N,N-diisopropylamine; acetyl chloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 99-36-5
1-methoxycarbonyl-3-methylbenzene

: 541548-49-6
5'-O-[3-(2-hydroxy-2-methylpropyl)sulfonylmethyl-4',4''-dimethoxytrityl]thymidine

Guidance literature:: Multi-step reaction with 11 steps

1.1: magnesium / tetrahydrofuran / 1 h / 20 °C

1.2: 81 percent / tetrahydrofuran / 1 h / 0 - 20 °C

2.1: acetyl chloride / 1 h / Heating

3.1: 43.2 g / pyridine / 0 °C

4.1: 77 percent Spectr_. / N-bromosuccinimide; N,N'-azobisisobutyronitrile / CCl₄ / 0.33 h / Heating

5.1: 32 g / N-ethyldiisopropylamine / dimethylformamide / 3 h / 20 °C

6.1: 74 percent / m-chloroperbenzoic acid; sodium bicarbonate / CH₂Cl₂ / 0.17 h / 0 °C

7.1: 90 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 20 °C

8.1: 96 percent / aqueous acetic acid / 1 h / 20 °C

9.1: 98 percent / acetyl chloride / toluene / 1 h / Heating

10.1: 95 percent / pyridine / 3 h / 20 °C

11.1: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 10 h / 20 °C

With pyridine; 2,6-dimethylpyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; sodium hydrogencarbonate; magnesium; acetic acid; N-ethyl-N,N-diisopropylamine; acetyl chloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene;