tert-butyl 3-methoxybenzyl((2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl)-carbamate

Base Information

Chemical Name:tert-butyl 3-methoxybenzyl((2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl)-carbamate
CAS No.:924650-42-0
Molecular Formula:C₂₃H₃₀F₂N₂O₄
Molecular Weight:436.499
Hs Code.:

Synonyms:tert-butyl 3-methoxybenzyl((2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl)-carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 3-methoxybenzyl((2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl)-carbamate

Chemical Property:

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Technology Process of tert-butyl 3-methoxybenzyl((2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl)-carbamate

There total 1 articles about tert-butyl 3-methoxybenzyl((2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1196490-43-3
C₃₁H₃₆F₂N₂O₆

: 924650-42-0
tert-butyl 3-methoxybenzyl((2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl)-carbamate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; under 2585.81 Torr;
DOI:10.1016/j.bmcl.2009.03.144

Reference yield:

: 924650-42-0
tert-butyl 3-methoxybenzyl((2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl)-carbamate

: 924650-07-7
C₃₇H₄₅F₂N₃O₇

Guidance literature:: 3-acetyl-5-(methyl(propyl)carbamoyl)benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 0.166667h;

tert-butyl 3-methoxybenzyl((2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl)-carbamate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 924650-42-0
tert-butyl 3-methoxybenzyl((2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl)-carbamate

: 924650-20-4
tert-butyl 3-methoxybenzyl((2R,3S)-3-(3-acetyl-5-(N-methylmethan-2-ylsulfonamido)benzamido)-4-(3,5-difluorophenyl)-2-hydroxybutyl)carbamate

Guidance literature:: 3-acetyl-5-(N-methylmethan-2-ylsulfonamido)benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 0.166667h;

tert-butyl 3-methoxybenzyl((2R,3S)-3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl)-carbamate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;