6-(4,5-dihydro-1H-imidazol-2-yl)-2-[4-[[[(4-pyridyl)methyl]amino]carbonyl]phenyl]indole

Base Information

Chemical Name:6-(4,5-dihydro-1H-imidazol-2-yl)-2-[4-[[[(4-pyridyl)methyl]amino]carbonyl]phenyl]indole
CAS No.:1551493-15-2
Molecular Formula:C₂₄H₂₁N₅O
Molecular Weight:395.464
Hs Code.:

Synonyms:6-(4,5-dihydro-1H-imidazol-2-yl)-2-[4-[[[(4-pyridyl)methyl]amino]carbonyl]phenyl]indole

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Chemical Property of 6-(4,5-dihydro-1H-imidazol-2-yl)-2-[4-[[[(4-pyridyl)methyl]amino]carbonyl]phenyl]indole

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Technology Process of 6-(4,5-dihydro-1H-imidazol-2-yl)-2-[4-[[[(4-pyridyl)methyl]amino]carbonyl]phenyl]indole

There total 6 articles about 6-(4,5-dihydro-1H-imidazol-2-yl)-2-[4-[[[(4-pyridyl)methyl]amino]carbonyl]phenyl]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1551493-92-5
6-cyano-2-[4-[[[(4-pyridyl)methyl]amino]carbonyl]phenyl]indole

: 107-15-3,85404-18-8
ethylenediamine

: 1551493-15-2
6-(4,5-dihydro-1H-imidazol-2-yl)-2-[4-[[[(4-pyridyl)methyl]amino]carbonyl]phenyl]indole

Guidance literature:: With sodium hydrogen sulfide; In N,N-dimethyl acetamide; at 120 ℃; for 2h;
DOI:10.1016/j.bmcl.2013.12.064

Reference yield:

: 1551493-73-2
C₁₇H₁₂N₂O₄

: 1551493-15-2
6-(4,5-dihydro-1H-imidazol-2-yl)-2-[4-[[[(4-pyridyl)methyl]amino]carbonyl]phenyl]indole

Guidance literature:: Multi-step reaction with 4 steps

1: bis(acetylacetonato)dioxidomolybdenum(VI); triethyl phosphite / 2 h / 130 °C

2: sodium hydroxide; water / N,N-dimethyl acetamide / 4 h / 70 °C

3: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 24 h / 20 °C

4: sodium hydrogen sulfide / N,N-dimethyl acetamide / 2 h / 120 °C

With sodium hydrogen sulfide; bis(acetylacetonato)dioxidomolybdenum(VI); water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; triethyl phosphite; In N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2013.12.064

Reference yield:

: 1551493-79-8
C₁₇H₁₂N₂O₂

: 1551493-15-2
6-(4,5-dihydro-1H-imidazol-2-yl)-2-[4-[[[(4-pyridyl)methyl]amino]carbonyl]phenyl]indole

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / N,N-dimethyl acetamide / 4 h / 70 °C

2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 24 h / 20 °C

3: sodium hydrogen sulfide / N,N-dimethyl acetamide / 2 h / 120 °C

With sodium hydrogen sulfide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2013.12.064