Cortolone

Base Information

Chemical Name:Cortolone
CAS No.:516-42-7
Molecular Formula:C₂₁H₃₄O₅
Molecular Weight:366.498
Hs Code.:
NSC Number:59872
UNII:3J9D9J550A
DSSTox Substance ID:DTXSID10904343
Nikkaji Number:J6.310J
Wikidata:Q27106233
Metabolomics Workbench ID:38254
ChEMBL ID:CHEMBL1908042
Mol file:516-42-7.mol

Synonyms:cortolone;cortolone, (3alpha,5alpha,20S)-isomer;cortolone, (3alpha,5beta,20R)-isomer

Suppliers and Price of Cortolone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
α-Cortolone
10 mg
$ 490.00

American Custom Chemicals Corporation
ALPHA-CORTOLONE 98.00%
500MG
$ 1963.50

American Custom Chemicals Corporation
ALPHA-CORTOLONE 98.00%
0.1G
$ 1444.30

American Custom Chemicals Corporation
ALPHA-CORTOLONE 98.00%
50MG
$ 750.75

AHH
alpha-Cortolone 98%
0.1g
$ 600.00

Total 20 raw suppliers

Chemical Property of Cortolone

Chemical Property:

Melting Point:208-209°
Boiling Point:564.1°Cat760mmHg
Flash Point:309°C
PSA：97.99000
Density:1.248g/cm³
LogP:1.65330
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly), Pyridine (Slightly)
XLogP3:1.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:366.24062418
Heavy Atom Count:26
Complexity:593

Purity/Quality:

99% ^*data from raw suppliers

α-Cortolone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC12CCC(CC1CCC3C2C(=O)CC4(C3CCC4(C(CO)O)O)C)O
Isomeric SMILES:C[C@]12CC[C@H](C[C@H]1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4([C@H](CO)O)O)C)O
Uses α-Cortolone is a human urinary metabolite of Cortisol ((H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.

Technology Process of Cortolone

There total 9 articles about Cortolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28439-40-9
3α,21-diacetoxy-17-hydroxy-5β-pregnane-11,20-dione

: 516-42-7
Cortolone

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; platinum / Hydrogenation.Behandlung der nach der Abtrennung von 17.20β_F-Dihydroxy-3α.21-diacetoxy-5β-pregnanon-(11) verbliebenen Anteile des Reaktionsprodukts mit Acetanhydrid und Pyridin

With acetic acid; platinum;

Reference yield:

: C₂₄H₃₈O₆

: 516-42-7
Cortolone

Guidance literature:: With hydrogenchloride; In methanol; Heating;
DOI:10.1016/S0040-4020(01)82212-2

Reference yield:

: 93206-77-0
methyl 20β-acetoxy-3α-tert-butyldimethylsilyloxy-17α-hydroxy-11-oxo-5β-pregnan-21-oate

: 516-42-7
Cortolone

Guidance literature:: Multi-step reaction with 5 steps

1: 410 mg / LiAlH₄ / diethyl ether / 1 h / Ambient temperature

2: 250 mg / pyridine / Ambient temperature

3: 110 mg / 10percent CrO₃-pyridine complex / pyridine / 1 h / Ambient temperature

4: 60 mg / 50percent H₂SO₄ / acetone / 0.17 h / Ambient temperature

5: saponification

With lithium aluminium tetrahydride; chromium trioxide-pyridine complex; sulfuric acid; In pyridine; diethyl ether; acetone;
DOI:10.1248/cpb.32.4023