N-(hydroxy(methyl)phosphinyl)-L-phenylalanine amide, triethylammonium salt

Base Information

• Chemical Name: N-(hydroxy(methyl)phosphinyl)-L-phenylalanine amide, triethylammonium salt
• CAS No.: 84621-25-0
• Molecular Formula: C₆H₁₅N*C₁₀H₁₅N₂O₃P
• Molecular Weight: 343.406
• Mol file: 84621-25-0.mol

Synonyms:N-(hydroxy(methyl)phosphinyl)-L-phenylalanine amide, triethylammonium salt

Chemical Property of N-(hydroxy(methyl)phosphinyl)-L-phenylalanine amide, triethylammonium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(hydroxy(methyl)phosphinyl)-L-phenylalanine amide, triethylammonium salt

There total 4 articles about N-(hydroxy(methyl)phosphinyl)-L-phenylalanine amide, triethylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triethylamine carbonate (15715-58-9) + N-(amino(methyl)phosphinyl)-L-phenylalanine methyl ester (84558-52-1,84558-53-2) → N-(hydroxy(methyl)phosphinyl)-L-phenylalanine, bis(triethylammonium) salt (84558-54-3) + N-(hydroxy(methyl)phosphinyl)-L-phenylalanine amide, triethylammonium salt (84621-25-0)

Guidance literature:

With sodium hydroxide; In water; at 21 ℃; for 0.25h;

DOI:10.1021/ja00344a032

Reference yield:

N-(methoxy(methyl)phosphinyl)-L-phenylalanine methyl ester (84558-46-3,84558-49-6) → N-(hydroxy(methyl)phosphinyl)-L-phenylalanine amide, triethylammonium salt (84621-25-0)

Guidance literature:

Multi-step reaction with 4 steps

1: PCl₅ / CHCl₃ / 5 h / 21 °C

2: Et₃N / CHCl₃ / 1 h / 21 °C

3: 6.4 mg / NH₃ gas / 2-methyl-propan-2-ol / 66 h / 21 °C

4: 1.) 1.9 M NaOH / H₂O / 0.25 h / 21 °C

With sodium hydroxide; phosphorus pentachloride; ammonia; triethylamine; In chloroform; water; tert-butyl alcohol;

DOI:10.1021/ja00344a032

Reference yield:

C11H15ClNO3P → N-(hydroxy(methyl)phosphinyl)-L-phenylalanine amide, triethylammonium salt (84621-25-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CHCl₃ / 1 h / 21 °C

2: 6.4 mg / NH₃ gas / 2-methyl-propan-2-ol / 66 h / 21 °C

3: 1.) 1.9 M NaOH / H₂O / 0.25 h / 21 °C

With sodium hydroxide; ammonia; triethylamine; In chloroform; water; tert-butyl alcohol;

DOI:10.1021/ja00344a032

upstream raw materials:

triethylamine carbonate

N-(amino(methyl)phosphinyl)-L-phenylalanine methyl ester

N-(methoxy(methyl)phosphinyl)-L-phenylalanine methyl ester

N-(methyl(phenylthio)phosphinyl)-L-phenylalanine methyl ester

Downstream raw materials:

N-(hydroxy(methyl)phosphinyl)-L-phenylalanine amide, sodium salt