N'-(4-Benzyl-3-methyl-5-oxo-4,5-dihydro-isoxazol-4-yl)-N,N-dimethyl-acetamidine

Base Information

Chemical Name:N'-(4-Benzyl-3-methyl-5-oxo-4,5-dihydro-isoxazol-4-yl)-N,N-dimethyl-acetamidine
CAS No.:133469-70-2
Molecular Formula:C₁₅H₁₉N₃O₂
Molecular Weight:273.335
Hs Code.:

Synonyms:N'-(4-Benzyl-3-methyl-5-oxo-4,5-dihydro-isoxazol-4-yl)-N,N-dimethyl-acetamidine

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Chemical Property of N'-(4-Benzyl-3-methyl-5-oxo-4,5-dihydro-isoxazol-4-yl)-N,N-dimethyl-acetamidine

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Technology Process of N'-(4-Benzyl-3-methyl-5-oxo-4,5-dihydro-isoxazol-4-yl)-N,N-dimethyl-acetamidine

There total 4 articles about N'-(4-Benzyl-3-methyl-5-oxo-4,5-dihydro-isoxazol-4-yl)-N,N-dimethyl-acetamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 127-19-5,116057-81-9
N,N-dimethyl acetamide

: 138528-26-4
4-Amino-4-benzyl-3-methyl-4H-isoxazol-5-one; hydrobromide

: 133469-70-2
N'-(4-Benzyl-3-methyl-5-oxo-4,5-dihydro-isoxazol-4-yl)-N,N-dimethyl-acetamidine

Guidance literature:: With trichlorophosphate; In chloroform; for 1.5h; Heating;
DOI:10.1055/s-1991-26396

Reference yield:

: 72745-66-5
3-methyl-4-benzyl-2-isoxazolin-5-one

: 133469-70-2
N'-(4-Benzyl-3-methyl-5-oxo-4,5-dihydro-isoxazol-4-yl)-N,N-dimethyl-acetamidine

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / Br₂ / CH₂Cl₂ / 0.17 h / Ambient temperature

2: 86 percent / NaN₃, tetrahexylammonium iodide (THAI) / H₂O; CH₂Cl₂ / 4 h / Ambient temperature

3: 91 percent / HBr / acetic acid / 0.5 h / 65 °C

4: 61 percent / POCl₃ / CHCl₃ / 1.5 h / Heating

With sodium azide; hydrogen bromide; bromine; tetrahexylammonium iodide; trichlorophosphate; In dichloromethane; chloroform; water; acetic acid;
DOI:10.1055/s-1991-26396

Reference yield:

: 68708-08-7
4-benzyl-4-bromo-3-methyl-4H-isoxazol-5-one

: 133469-70-2
N'-(4-Benzyl-3-methyl-5-oxo-4,5-dihydro-isoxazol-4-yl)-N,N-dimethyl-acetamidine

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / NaN₃, tetrahexylammonium iodide (THAI) / H₂O; CH₂Cl₂ / 4 h / Ambient temperature

2: 91 percent / HBr / acetic acid / 0.5 h / 65 °C

3: 61 percent / POCl₃ / CHCl₃ / 1.5 h / Heating

With sodium azide; hydrogen bromide; tetrahexylammonium iodide; trichlorophosphate; In dichloromethane; chloroform; water; acetic acid;
DOI:10.1055/s-1991-26396