((Z)-1-Chloromethyl-6,6-dimethoxy-3-methyl-hex-2-enyloxy)-triisopropyl-silane

Base Information

• Chemical Name: ((Z)-1-Chloromethyl-6,6-dimethoxy-3-methyl-hex-2-enyloxy)-triisopropyl-silane
• CAS No.: 367278-11-3
• Molecular Formula: C₁₉H₃₉ClO₃Si
• Molecular Weight: 379.055
• Mol file: 367278-11-3.mol

Synonyms:((Z)-1-Chloromethyl-6,6-dimethoxy-3-methyl-hex-2-enyloxy)-triisopropyl-silane

Chemical Property of ((Z)-1-Chloromethyl-6,6-dimethoxy-3-methyl-hex-2-enyloxy)-triisopropyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((Z)-1-Chloromethyl-6,6-dimethoxy-3-methyl-hex-2-enyloxy)-triisopropyl-silane

There total 1 articles about ((Z)-1-Chloromethyl-6,6-dimethoxy-3-methyl-hex-2-enyloxy)-triisopropyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triisopropylsilyl trifluoromethanesulfonate (80522-42-5) + (Z)-7-chloro-6-hydroxy-1,1-dimethoxy-4-methylhept-4-ene (367278-08-8) → ((Z)-1-Chloromethyl-6,6-dimethoxy-3-methyl-hex-2-enyloxy)-triisopropyl-silane (367278-11-3)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1021/ja0109491

Reference yield:

((Z)-1-Chloromethyl-6,6-dimethoxy-3-methyl-hex-2-enyloxy)-triisopropyl-silane (367278-11-3) → (Z)-[3(2R,3S)4R]-3-[7-chloro-3-hydroxy-8-(triisopropylsilyloxy)-2,6-dimethyl-1-oxonon-6-ene]-4-benzyl-2-oxazolidinone (367278-13-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 11 g / trifluoroacetic acid / CH₂Cl₂; H₂O / 2 h / 20 °C

2.1: n-dibutylborontriflate / CH₂Cl₂ / 0.17 h / 0 °C

2.2: 59 percent / triethylamine / CH₂Cl₂ / 3 h / -78 °C

With n-dibutylborontriflate; trifluoroacetic acid; In dichloromethane; water; 2.1: Evans asymmetric aldolization;

DOI:10.1021/ja0109491

upstream raw materials:

triisopropylsilyl trifluoromethanesulfonate

(Z)-7-chloro-6-hydroxy-1,1-dimethoxy-4-methylhept-4-ene

Downstream raw materials:

(Z)-[3(2R,3S)4R]-3-[7-chloro-3-hydroxy-8-(triisopropylsilyloxy)-2,6-dimethyl-1-oxonon-6-ene]-4-benzyl-2-oxazolidinone