2-[({4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

Base Information

Chemical Name:2-[({4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide
CAS No.:1245940-96-8
Molecular Formula:C₂₄H₂₁F₆N₅O₄
Molecular Weight:557.452
Hs Code.:

Synonyms:2-[({4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

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Chemical Property of 2-[({4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

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Technology Process of 2-[({4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

There total 7 articles about 2-[({4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1183104-54-2
2-amino-2-[3-(trifluoromethyl)phenyl]propanamide

: 1245940-72-0
{4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

: 1245940-96-8
2-[({4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

Guidance literature:: {4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid; With N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

2-amino-2-[3-(trifluoromethyl)phenyl]propanamide; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 1245940-69-5
N-Cyclopropyl-2-{[2-(trifluoromethoxy)phenyl]carbonyl}hydrazinecarboxamide

: 1245940-96-8
2-[({4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water / 96 h / Reflux

1.2: pH 10

2.1: caesium carbonate / acetonitrile; water / 2 h / Reflux

3.1: lithium hydroxide / methanol / 0.5 h / 20 °C

4.1: benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 12 h / 20 °C

With N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; benzotriazol-1-ol; caesium carbonate; sodium hydroxide; lithium hydroxide; In methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 349-76-8
3'-(trifluoromethyl)acetophenone

: 1245940-96-8
2-[({4-Cyclopropyl-5-oxo-3-[2-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia; ammonium chloride / ethanol; water / 20 h / 70 °C / Autoclave

2.1: hydrogenchloride; water / 20 °C / Cooling with ice

3.1: benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 12 h / 20 °C

With hydrogenchloride; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; ammonia; water; ammonium chloride; benzotriazol-1-ol; In ethanol; water; N,N-dimethyl-formamide;