(S)-3-[(1H-benzoimidazole-4-carbonyl)-amino]-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid (HCl salt)

Base Information

Chemical Name:(S)-3-[(1H-benzoimidazole-4-carbonyl)-amino]-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid (HCl salt)
CAS No.:1400660-84-5
Molecular Formula:C₂₅H₂₃N₅O₆S*ClH
Molecular Weight:558.014
Hs Code.:

Synonyms:(S)-3-[(1H-benzoimidazole-4-carbonyl)-amino]-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid (HCl salt)

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Chemical Property of (S)-3-[(1H-benzoimidazole-4-carbonyl)-amino]-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid (HCl salt)

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Technology Process of (S)-3-[(1H-benzoimidazole-4-carbonyl)-amino]-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid (HCl salt)

There total 12 articles about (S)-3-[(1H-benzoimidazole-4-carbonyl)-amino]-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid (HCl salt) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400663-10-6
C₂₆H₂₅N₅O₆S

: 1400660-84-5
(S)-3-[(1H-benzoimidazole-4-carbonyl)-amino]-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid (HCl salt)

Guidance literature:: C₂₆H₂₅N₅O₆S; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 40 ℃; for 0.833333h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 873-62-1
m-cyanophenol

: 1400660-84-5
(S)-3-[(1H-benzoimidazole-4-carbonyl)-amino]-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid (HCl salt)

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 4.5 h / 20 °C / 2585.81 Torr

3.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h / 20 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1.5 h / 20 °C

5.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

7.1: hydrogenchloride; triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

7.2: pH 7 buffer

8.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.83 h / 40 °C

With 1H-imidazole; hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 160833-27-2
3-(tert-butyldimethylsilyloxy)benzonitrile

: 1400660-84-5
(S)-3-[(1H-benzoimidazole-4-carbonyl)-amino]-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid (HCl salt)

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 4.5 h / 20 °C / 2585.81 Torr

2.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1.5 h / 20 °C

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1.5 h / 20 °C

4.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

6.1: hydrogenchloride; triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

6.2: pH 7 buffer

7.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.83 h / 40 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;