4-(3,4-dimethoxyphenyl)-1-methoxy-5H-<1>benzothiopyrano<4,3-b>pyridine-3-carbonitrile-6-sulfone

Base Information

• Chemical Name: 4-(3,4-dimethoxyphenyl)-1-methoxy-5H-<1>benzothiopyrano<4,3-b>pyridine-3-carbonitrile-6-sulfone
• CAS No.: 135521-81-2
• Molecular Formula: C₂₂H₁₈N₂O₅S
• Molecular Weight: 422.461
• Mol file: 135521-81-2.mol

Synonyms:4-(3,4-dimethoxyphenyl)-1-methoxy-5H-<1>benzothiopyrano<4,3-b>pyridine-3-carbonitrile-6-sulfone

Chemical Property of 4-(3,4-dimethoxyphenyl)-1-methoxy-5H-<1>benzothiopyrano<4,3-b>pyridine-3-carbonitrile-6-sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,4-dimethoxyphenyl)-1-methoxy-5H-<1>benzothiopyrano<4,3-b>pyridine-3-carbonitrile-6-sulfone

There total 4 articles about 4-(3,4-dimethoxyphenyl)-1-methoxy-5H-<1>benzothiopyrano<4,3-b>pyridine-3-carbonitrile-6-sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.1%

4-(3,4-dimethoxyphenyl)-2-methoxy-<1>benzothio-5H-pyrano<4,3-b>pyridine-3-carbonitrile (115091-87-7) → 4-(3,4-dimethoxyphenyl)-1-methoxy-5H-<1>benzothiopyrano<4,3-b>pyridine-3-carbonitrile-6-sulfone (135521-81-2)

Guidance literature:

With dihydrogen peroxide; acetic acid; for 18h; Ambient temperature;

DOI:10.1016/0223-5234(91)90033-J

Reference yield:

3-[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-thiochroman-4-one (130688-99-2) → 4-(3,4-dimethoxyphenyl)-1-methoxy-5H-<1>benzothiopyrano<4,3-b>pyridine-3-carbonitrile-6-sulfone (135521-81-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 62.6 percent / NaOH / 16 h

2: 64.1 percent / H₂O₂ / acetic acid / 18 h / 20 °C

With sodium hydroxide; dihydrogen peroxide; In acetic acid;

Reference yield:

2,3-dihydro-4H-[1]benzothiopyran-4-one (3528-17-4) → 4-(3,4-dimethoxyphenyl)-1-methoxy-5H-<1>benzothiopyrano<4,3-b>pyridine-3-carbonitrile-6-sulfone (135521-81-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 50.7 percent / HCl / ethanol

2: 62.6 percent / NaOH / 16 h

3: 64.1 percent / H₂O₂ / acetic acid / 18 h / 20 °C

With hydrogenchloride; sodium hydroxide; dihydrogen peroxide; In ethanol; acetic acid;

upstream raw materials:

4-(3,4-dimethoxyphenyl)-2-methoxy-<1>benzothio-5H-pyrano<4,3-b>pyridine-3-carbonitrile

2,3-dihydro-4H-[1]benzothiopyran-4-one

3-[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-thiochroman-4-one

3,4-dimethoxy-benzaldehyde