tert-butyl ((4aS,5S_.7aS)-7a-(5-(5-(difluoromethyl)pyrazine-2-carboxamido)-2-fluorophenyl)-3-methyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

Base Information

• Chemical Name: tert-butyl ((4aS,5S_.7aS)-7a-(5-(5-(difluoromethyl)pyrazine-2-carboxamido)-2-fluorophenyl)-3-methyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate
• CAS No.: 1262799-45-0
• Molecular Formula: C₂₅H₂₄F₆N₆O₅
• Molecular Weight: 602.493

Synonyms:tert-butyl ((4aS,5S_.7aS)-7a-(5-(5-(difluoromethyl)pyrazine-2-carboxamido)-2-fluorophenyl)-3-methyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

Chemical Property of tert-butyl ((4aS,5S_.7aS)-7a-(5-(5-(difluoromethyl)pyrazine-2-carboxamido)-2-fluorophenyl)-3-methyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl ((4aS,5S_.7aS)-7a-(5-(5-(difluoromethyl)pyrazine-2-carboxamido)-2-fluorophenyl)-3-methyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

There total 6 articles about tert-butyl ((4aS,5S_.7aS)-7a-(5-(5-(difluoromethyl)pyrazine-2-carboxamido)-2-fluorophenyl)-3-methyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(difluoromethyl)pyrazine-2-carboxylic acid (1174321-06-2) + tert-butyl ((4aS,5S,7aS)-7a-(5-amino-2-fluorophenyl)-3-methyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate (1262799-44-9) → tert-butyl ((4aS,5S.7aS)-7a-(5-(5-(difluoromethyl)pyrazine-2-carboxamido)-2-fluorophenyl)-3-methyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate (1262799-45-0)

Guidance literature:

With (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

2-methylpyrazin-5-carboxylic acid (5521-55-1) → tert-butyl ((4aS,5S.7aS)-7a-(5-(5-(difluoromethyl)pyrazine-2-carboxamido)-2-fluorophenyl)-3-methyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate (1262799-45-0)

Guidance literature:

Multi-step reaction with 6 steps

1: boron trifluoride diethyl etherate / tetrahydrofuran / 20 °C / Ice-cooling

2: N,N-dimethyl-formamide / 5 h / 130 °C

3: sodium periodate / water; tetrahydrofuran / 4 h / 20 °C

4: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 2 h / 20 °C / Inert atmosphere; Ice-cooling

5: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate / dichloromethane / 16 h / 20 °C / Inert atmosphere

With sodium periodate; (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate; boron trifluoride diethyl etherate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

t-butyl 5-formylpyrazine-2-carboxylate (1174321-08-4) → tert-butyl ((4aS,5S.7aS)-7a-(5-(5-(difluoromethyl)pyrazine-2-carboxamido)-2-fluorophenyl)-3-methyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate (1262799-45-0)

Guidance literature:

Multi-step reaction with 3 steps

1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 2 h / 20 °C / Inert atmosphere; Ice-cooling

2: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate / dichloromethane / 16 h / 20 °C / Inert atmosphere

With (benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane;

upstream raw materials:

2-methylpyrazin-5-carboxylic acid

t-butyl 5-methylpyrazine-2-carboxylate

5-(difluoromethyl)pyrazine-2-carboxylic acid

tert-butyl ((4aS,5S,7aS)-7a-(5-amino-2-fluorophenyl)-3-methyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

Downstream raw materials:

N-(3-((4aS,5S,7aS)-2-amino-3-methyl-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-7a-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide

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