4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperazinecarboxamide

Base Information

Chemical Name:4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperazinecarboxamide
CAS No.:1148046-16-5
Molecular Formula:C₂₅H₂₇N₅O₂S
Molecular Weight:461.588
Hs Code.:

Synonyms:4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperazinecarboxamide

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Chemical Property of 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperazinecarboxamide

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Technology Process of 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperazinecarboxamide

There total 3 articles about 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1003320-11-3
1-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-piperazine hydrochloride

: 32315-10-9
bis(trichloromethyl) carbonate

: 95-78-3
2,5-Dimethylaniline

: 1148046-16-5
4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperazinecarboxamide

Guidance literature:: bis(trichloromethyl) carbonate; 2,5-Dimethylaniline; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

1-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-piperazine hydrochloride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

: 1,1-dimethylethyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperazine acetate

: 1148046-16-5
4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperazinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / diethyl ether; methanol / 8 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 20 °C

2.2: 2 h / 0 - 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether;

Reference yield:

: 1003320-09-9
2-chloro-1-(4,5-dihydro-5-phenyl-3-isoxazolyl)ethanone

: 1148046-16-5
4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-N-(2,5-dimethylphenyl)-1-piperazinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / ethanol / 12 h / 20 °C

2.1: hydrogenchloride / diethyl ether; methanol / 8 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 20 °C

3.2: 2 h / 0 - 20 °C

With hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol;