tert-butyl 4-{[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)carbamoyl}-1-piperazinecarboxylate

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Chemical Name:tert-butyl 4-{[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)carbamoyl}-1-piperazinecarboxylate
CAS No.:1620482-63-4
Molecular Formula:C₃₂H₃₉N₉O₄
Molecular Weight:613.72
Hs Code.:

Synonyms:tert-butyl 4-{[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)carbamoyl}-1-piperazinecarboxylate

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Chemical Property of tert-butyl 4-{[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)carbamoyl}-1-piperazinecarboxylate

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Technology Process of tert-butyl 4-{[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)carbamoyl}-1-piperazinecarboxylate

There total 4 articles about tert-butyl 4-{[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)carbamoyl}-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1639450-57-9
C₂₃H₂₂ClN₇O₂

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1620482-63-4
tert-butyl 4-{[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)carbamoyl}-1-piperazinecarboxylate

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 60 ℃;
DOI:10.1021/ja505517t

Reference yield:

: 1620483-11-5
{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methanol

: 1620482-63-4
tert-butyl 4-{[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)carbamoyl}-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfur trioxide pyridine complex; triethylamine / ethyl acetate; dimethyl sulfoxide / 0.33 h / 0 - 20 °C / Inert atmosphere

2: trimethylsilylazide / methanol / 0 - 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C

4: N-ethyl-N,N-diisopropylamine; dmap / tetrahydrofuran / 60 °C

With dmap; trimethylsilylazide; sulfur trioxide pyridine complex; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/ja505517t

Reference yield:

: 1620483-12-6
4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]benzaldehyde

: 1620482-63-4
tert-butyl 4-{[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl](2-propyn-1-yl)carbamoyl}-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylsilylazide / methanol / 0 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C

3: N-ethyl-N,N-diisopropylamine; dmap / tetrahydrofuran / 60 °C

With dmap; trimethylsilylazide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;
DOI:10.1021/ja505517t