2-(4-methoxy-2-methylphenyl)-3-(4-methoxyphenyl)propionitrile

Base Information

• Chemical Name: 2-(4-methoxy-2-methylphenyl)-3-(4-methoxyphenyl)propionitrile
• CAS No.: 380915-29-7
• Molecular Formula: C₁₈H₁₉NO₂
• Molecular Weight: 281.354
• Mol file: 380915-29-7.mol

Synonyms:2-(4-methoxy-2-methylphenyl)-3-(4-methoxyphenyl)propionitrile

Chemical Property of 2-(4-methoxy-2-methylphenyl)-3-(4-methoxyphenyl)propionitrile

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(4-methoxy-2-methylphenyl)-3-(4-methoxyphenyl)propionitrile

There total 2 articles about 2-(4-methoxy-2-methylphenyl)-3-(4-methoxyphenyl)propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(Z)-2-(4-methoxy-2-methylphenyl)-3-(4-methoxyphenyl)acrylonitrile (380914-75-0) → 2-(4-methoxy-2-methylphenyl)-3-(4-methoxyphenyl)propionitrile (380915-29-7)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 14h; Heating;

DOI:10.1021/jm010254a

Reference yield:

2-(4-methoxy-2-methylphenyl)acetonitrile (262298-02-2) → 2-(4-methoxy-2-methylphenyl)-3-(4-methoxyphenyl)propionitrile (380915-29-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 39 percent / aq. KOH / ethanol

2: 68 percent / NaBH₄ / ethanol / 14 h / Heating

With potassium hydroxide; sodium tetrahydroborate; In ethanol;

DOI:10.1021/jm010254a

Reference yield: 75.0%

2-(4-methoxy-2-methylphenyl)-3-(4-methoxyphenyl)propionitrile (380915-29-7) → 2-(4-hydroxy-2-methyl-phenyl)-3-(4-hydroxy-phenyl)-propionitrile

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/jm010254a

upstream raw materials:

(Z)-2-(4-methoxy-2-methylphenyl)-3-(4-methoxyphenyl)acrylonitrile

2-(4-methoxy-2-methylphenyl)acetonitrile