(R)-2-(2-Phenyl-[1,3]dioxolan-2-ylmethyl)-piperidine-1-carboxylic acid methyl ester

Base Information

Chemical Name:(R)-2-(2-Phenyl-[1,3]dioxolan-2-ylmethyl)-piperidine-1-carboxylic acid methyl ester
CAS No.:98712-00-6
Molecular Formula:C₁₇H₂₃NO₄
Molecular Weight:305.374
Hs Code.:

Synonyms:(R)-2-(2-Phenyl-[1,3]dioxolan-2-ylmethyl)-piperidine-1-carboxylic acid methyl ester

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Chemical Property of (R)-2-(2-Phenyl-[1,3]dioxolan-2-ylmethyl)-piperidine-1-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (R)-2-(2-Phenyl-[1,3]dioxolan-2-ylmethyl)-piperidine-1-carboxylic acid methyl ester

There total 5 articles about (R)-2-(2-Phenyl-[1,3]dioxolan-2-ylmethyl)-piperidine-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 185385-20-0
6-methoxy-1-methoxycarbonylpipecolate

: 98712-00-6
(R)-2-(2-Phenyl-[1,3]dioxolan-2-ylmethyl)-piperidine-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: TiCl₄ / CH₂Cl₂ / -50 °C

2: 96 percent / p-MeC₆H₄SO₃H / benzene / 21 h / Heating

3: 93 percent / NaOH / methanol; H₂O / 3.5 h

4: 84 percent / MeONa, carbon anode

5: 1.) NH₄Cl, 2.) H₂ / 2.) Pd/C / 1.) toluene, reflux, 2 h, 2.) AcOEt

With sodium hydroxide; hydrogen; sodium methylate; titanium tetrachloride; ammonium chloride; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; dichloromethane; water; benzene;
DOI:10.1039/c39850000633

Reference yield:

: 691898-58-5
(S)-6-Methoxycarbonylamino-piperidine-1,2-dicarboxylic acid dimethyl ester

: 98712-00-6
(R)-2-(2-Phenyl-[1,3]dioxolan-2-ylmethyl)-piperidine-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / p-MeC₆H₄SO₃H / 30 h / Ambient temperature

2: TiCl₄ / CH₂Cl₂ / -50 °C

3: 96 percent / p-MeC₆H₄SO₃H / benzene / 21 h / Heating

4: 93 percent / NaOH / methanol; H₂O / 3.5 h

5: 84 percent / MeONa, carbon anode

6: 1.) NH₄Cl, 2.) H₂ / 2.) Pd/C / 1.) toluene, reflux, 2 h, 2.) AcOEt

With sodium hydroxide; hydrogen; sodium methylate; titanium tetrachloride; ammonium chloride; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; dichloromethane; water; benzene;
DOI:10.1039/c39850000633

Reference yield:

: 98712-02-8
(2S,6R)-6-(2-Phenyl-[1,3]dioxolan-2-ylmethyl)-piperidine-1,2-dicarboxylic acid dimethyl ester

: 98712-00-6
(R)-2-(2-Phenyl-[1,3]dioxolan-2-ylmethyl)-piperidine-1-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / NaOH / methanol; H₂O / 3.5 h

2: 84 percent / MeONa, carbon anode

3: 1.) NH₄Cl, 2.) H₂ / 2.) Pd/C / 1.) toluene, reflux, 2 h, 2.) AcOEt

With sodium hydroxide; hydrogen; sodium methylate; ammonium chloride; palladium on activated charcoal; In methanol; water;
DOI:10.1039/c39850000633