Technology Process of 2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(methyl-d3)phenol
There total 9 articles about 2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(methyl-d3)phenol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
for 10h;
under 1520.1 Torr;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 1 h
2.1: N-Bromosuccinimide; ammonium acetate / acetonitrile / 3 h
3.1: iodine; magnesium / tetrahydrofuran / 1 h / 80 °C
3.2: 1 h / -30 °C
3.3: -30 - 20 °C
4.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 4 h / 20 °C
4.2: pH 2
5.1: pyridine; thionyl chloride / toluene / 1 h / Reflux
6.1: triethylamine / diethyl ether / 4 h
7.1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 20 °C
8.1: hydrogen / palladium 10% on activated carbon / methanol / 10 h / 1520.1 Torr
With
pyridine; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; ammonium acetate; hydrogen; dihydrogen peroxide; iodine; magnesium; triethylamine; lithium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; diethyl ether; hexane; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-Bromosuccinimide; ammonium acetate / acetonitrile / 3 h
2.1: iodine; magnesium / tetrahydrofuran / 1 h / 80 °C
2.2: 1 h / -30 °C
2.3: -30 - 20 °C
3.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 4 h / 20 °C
3.2: pH 2
4.1: pyridine; thionyl chloride / toluene / 1 h / Reflux
5.1: triethylamine / diethyl ether / 4 h
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 20 °C
7.1: hydrogen / palladium 10% on activated carbon / methanol / 10 h / 1520.1 Torr
With
pyridine; N-Bromosuccinimide; lithium aluminium tetrahydride; thionyl chloride; ammonium acetate; hydrogen; dihydrogen peroxide; iodine; magnesium; triethylamine; lithium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; diethyl ether; water; toluene; acetonitrile;
