1-(2-(3-aminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-2,2-dimethylpropan-1-one

Base Information

Chemical Name:1-(2-(3-aminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-2,2-dimethylpropan-1-one
CAS No.:885059-68-7
Molecular Formula:C₂₂H₂₅F₂N₃OS
Molecular Weight:417.523
Hs Code.:

Synonyms:1-(2-(3-aminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-2,2-dimethylpropan-1-one

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Chemical Property of 1-(2-(3-aminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-2,2-dimethylpropan-1-one

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Technology Process of 1-(2-(3-aminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-2,2-dimethylpropan-1-one

There total 8 articles about 1-(2-(3-aminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-2,2-dimethylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 885065-16-7
1-(2-(3-azidopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-2,2-dimethylpropan-1-one

: 885059-68-7
1-(2-(3-aminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-2,2-dimethylpropan-1-one

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 0.75h; under 760.051 Torr;

Reference yield:

: 885060-36-6
2,5-difluoro-benzothiohydrazide

: 885059-68-7
1-(2-(3-aminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-2,2-dimethylpropan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol; dichloromethane / 16 h / 20 °C

1.2: 16 h / 20 °C

2.1: triethylamine / dichloromethane / 12 h / 20 °C

3.1: hydrogenchloride; hydrogen / palladium on activated charcoal / methanol / 0.75 h / 20 °C / 760.05 Torr

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane;

Reference yield:

: 1021853-64-4
C₇H₄F₂S₂

: 885059-68-7
1-(2-(3-aminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-2,2-dimethylpropan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / water / 14 h / 20 °C

2.1: sodium hydroxide; hydrazine / 14 h / 0 - 20 °C

3.1: ethanol; dichloromethane / 16 h / 20 °C

3.2: 16 h / 20 °C

4.1: triethylamine / dichloromethane / 12 h / 20 °C

5.1: hydrogenchloride; hydrogen / palladium on activated charcoal / methanol / 0.75 h / 20 °C / 760.05 Torr

With hydrogenchloride; sodium hydroxide; hydrogen; sodium hydrogencarbonate; triethylamine; hydrazine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water;