2-(4-(3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)phenoxy)acetic acid hydrazide

Base Information

• Chemical Name: 2-(4-(3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)phenoxy)acetic acid hydrazide
• CAS No.: 1385073-65-3
• Molecular Formula: C₂₁H₂₇N₃O₆
• Molecular Weight: 417.462
• Mol file: 1385073-65-3.mol

Synonyms:2-(4-(3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)phenoxy)acetic acid hydrazide

Chemical Property of 2-(4-(3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)phenoxy)acetic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)phenoxy)acetic acid hydrazide

There total 4 articles about 2-(4-(3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)phenoxy)acetic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

diethyl 4-(4-(2-ethoxy-2-oxoethoxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (1385073-61-9) → 2-(4-(3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)phenoxy)acetic acid hydrazide (1385073-65-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Reflux;

DOI:10.1007/s00044-012-0156-1

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 2-(4-(3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)phenoxy)acetic acid hydrazide (1385073-65-3)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate / ethanol / 12 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 20 h / 80 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 4 h / Reflux

With ammonium acetate; potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide; 1: |Hantzsch Dihydropyridine Synthesis;

DOI:10.1007/s00044-012-0156-1

Reference yield:

4-(4-hydroxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (10354-30-0) → 2-(4-(3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridin-4-yl)phenoxy)acetic acid hydrazide (1385073-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 80 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / 4 h / Reflux

With potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1007/s00044-012-0156-1

upstream raw materials:

4-hydroxy-benzaldehyde

4-(4-hydroxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

ethyl acetoacetate

diethyl 4-(4-(2-ethoxy-2-oxoethoxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Downstream raw materials:

C₂₉H₃₃N₃O₇

C₂₈H₃₁N₃O₇

C₂₆H₂₈ClN₃O₇S

C₂₆H₂₉N₃O₇S