(1'R,2'S,4S)-4-<2'-<<(tert-butyloxy)carbonyl>amino>-3'-cyclohexyl-1'-<(methoxyethoxy)methoxy>propyl>-1-ethylimidazolidin-2-one

Base Information

Chemical Name:(1'R,2'S,4S)-4-<2'-<<(tert-butyloxy)carbonyl>amino>-3'-cyclohexyl-1'-<(methoxyethoxy)methoxy>propyl>-1-ethylimidazolidin-2-one
CAS No.:122225-17-6
Molecular Formula:C₂₃H₄₃N₃O₆
Molecular Weight:457.611
Hs Code.:

Synonyms:(1'R,2'S,4S)-4-<2'-<<(tert-butyloxy)carbonyl>amino>-3'-cyclohexyl-1'-<(methoxyethoxy)methoxy>propyl>-1-ethylimidazolidin-2-one

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Chemical Property of (1'R,2'S,4S)-4-<2'-<<(tert-butyloxy)carbonyl>amino>-3'-cyclohexyl-1'-<(methoxyethoxy)methoxy>propyl>-1-ethylimidazolidin-2-one

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Technology Process of (1'R,2'S,4S)-4-<2'-<<(tert-butyloxy)carbonyl>amino>-3'-cyclohexyl-1'-<(methoxyethoxy)methoxy>propyl>-1-ethylimidazolidin-2-one

There total 6 articles about (1'R,2'S,4S)-4-<2'-<<(tert-butyloxy)carbonyl>amino>-3'-cyclohexyl-1'-<(methoxyethoxy)methoxy>propyl>-1-ethylimidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 122225-99-4,127305-95-7
(2S,3S,4S)-2-amino-4-<<(tert-butyloxy)carbonyl>amino>-5-cyclohexyl-1-(ethylamino)-3-<(methoxyethoxy)methoxy>pentane

: 530-62-1
1,1'-carbonyldiimidazole

: 122225-17-6
(1'R,2'S,4S)-4-<2'-<<(tert-butyloxy)carbonyl>amino>-3'-cyclohexyl-1'-<(methoxyethoxy)methoxy>propyl>-1-ethylimidazolidin-2-one

Guidance literature:: In dichloromethane; for 6h; Ambient temperature;
DOI:10.1021/jm00168a009

Reference yield:

: 120476-92-8,120574-36-9,124150-91-0
(2RS,3R,4S)-4-<(tert-butyloxycarbonyl)amino>-5-cyclohexyl-3-<(2-methoxyethoxy)methoxy>-1,2-epoxypentane

: 122225-17-6
(1'R,2'S,4S)-4-<2'-<<(tert-butyloxy)carbonyl>amino>-3'-cyclohexyl-1'-<(methoxyethoxy)methoxy>propyl>-1-ethylimidazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: methanol; H₂O / 18 h

2: Et₃N / CH₂Cl₂ / 1.) a) 0 deg C, 15 min, b) RT, 30 min

3: 82 percent / NaN₃, H₂SO₄, (C₆H₅)3P, diethyl azodicarboxylate / tetrahydrofuran; benzene / 1.) a) -78 deg C, 1 h, b) RT, 16 h

4: 93 percent / Et₃N, 1,3-propanedithiol / methanol / 72 h

5: H₂, acetic acid / 20percent Pd/C / 23 h / 3040 Torr

6: 22 percent / CH₂Cl₂ / 6 h / Ambient temperature

With 1.3-propanedithiol; sodium azide; sulfuric acid; hydrogen; acetic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; benzene;
DOI:10.1021/jm00168a009

Reference yield:

: 122225-98-3,127308-27-4
(2S,3S,4S)-2-amino-1-<<(benzyloxy)carbonyl>ethylamino>-4-<<(tert-butyloxy)carbonyl>amino>-5-cyclohexyl-3-<(methoxyethoxy)methoxy>pentane

: 122225-17-6
(1'R,2'S,4S)-4-<2'-<<(tert-butyloxy)carbonyl>amino>-3'-cyclohexyl-1'-<(methoxyethoxy)methoxy>propyl>-1-ethylimidazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: H₂, acetic acid / 20percent Pd/C / 23 h / 3040 Torr

2: 22 percent / CH₂Cl₂ / 6 h / Ambient temperature

With hydrogen; acetic acid; palladium on activated charcoal; In dichloromethane;
DOI:10.1021/jm00168a009