1-Benzyl-5S-hydroxy-3,4-dehydro-2-piperidon

Base Information

Chemical Name:1-Benzyl-5S-hydroxy-3,4-dehydro-2-piperidon
CAS No.:134746-53-5
Molecular Formula:C₁₂H₁₃NO₂
Molecular Weight:203.241
Hs Code.:

Synonyms:1-Benzyl-5S-hydroxy-3,4-dehydro-2-piperidon

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Chemical Property of 1-Benzyl-5S-hydroxy-3,4-dehydro-2-piperidon

Chemical Property:

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Technology Process of 1-Benzyl-5S-hydroxy-3,4-dehydro-2-piperidon

There total 9 articles about 1-Benzyl-5S-hydroxy-3,4-dehydro-2-piperidon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 134746-51-3
1-Benzyl-5S-benzyloxy-3,4-dehydro-2-piperidon

: 134746-53-5
1-Benzyl-5S-hydroxy-3,4-dehydro-2-piperidon

Guidance literature:: With dimethylsulfide; boron trifluoride diethyl etherate; In dichloromethane; at 30 ℃; for 48h;
DOI:10.1002/ardp.19913240503

Reference yield:

: 30725-00-9
2,3-O-isopropylidene-D-ribonic-γ-lactone

: 134746-53-5
1-Benzyl-5S-hydroxy-3,4-dehydro-2-piperidon

Guidance literature:: Multi-step reaction with 8 steps

1: 86 percent / Et₃N / CH₂Cl₂ / 1) - 30 deg C, 5 min, 2) r.t., 2h

2: 75 percent / sodium azide / acetonitrile / 16 h / Heating

3: 73 percent / H₂ / Pd/C / methanol / 3 h / 30 °C

4: 64 percent / KOH / dimethylsulfoxide

5: 80 percent / 60percent acetic acid / 3 h / Heating

6: 75 percent / tetrahydrofuran / 3 h / Heating

7: 70 percent / Raney-Ni / tetrahydrofuran / 0.5 h / 60 °C

8: 51 percent / BF₃*OEt₂, (CH₃)2S / CH₂Cl₂ / 48 h / 30 °C

With potassium hydroxide; sodium azide; dimethylsulfide; boron trifluoride diethyl etherate; hydrogen; nickel; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1002/ardp.19913240503

Reference yield:

: 23709-18-4
(3aR,6R,6aR)-6-(azidomethyl)-2,2-dimethyldihydrofuro[3,4-d][1,3]dioxol-4(3aH)-one

: 134746-53-5
1-Benzyl-5S-hydroxy-3,4-dehydro-2-piperidon

Guidance literature:: Multi-step reaction with 6 steps

1: 73 percent / H₂ / Pd/C / methanol / 3 h / 30 °C

2: 64 percent / KOH / dimethylsulfoxide

3: 80 percent / 60percent acetic acid / 3 h / Heating

4: 75 percent / tetrahydrofuran / 3 h / Heating

5: 70 percent / Raney-Ni / tetrahydrofuran / 0.5 h / 60 °C

6: 51 percent / BF₃*OEt₂, (CH₃)2S / CH₂Cl₂ / 48 h / 30 °C

With potassium hydroxide; dimethylsulfide; boron trifluoride diethyl etherate; hydrogen; nickel; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1002/ardp.19913240503