N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2,6-dichloro-3-(2,2,2-trifluoro-1,1-dimethyl-ethyl)carbonylaminomethyl-benzamide

Base Information

Chemical Name:N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2,6-dichloro-3-(2,2,2-trifluoro-1,1-dimethyl-ethyl)carbonylaminomethyl-benzamide
CAS No.:1294494-84-0
Molecular Formula:C₂₈H₂₃BrCl₂F₅N₃O₄
Molecular Weight:711.31
Hs Code.:

N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2,6-dichloro-3-(2,2,2-trifluoro-1,1-dimethyl-ethyl)carbonylaminomethyl-benzamide

Synonyms:N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2,6-dichloro-3-(2,2,2-trifluoro-1,1-dimethyl-ethyl)carbonylaminomethyl-benzamide

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Chemical Property of N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2,6-dichloro-3-(2,2,2-trifluoro-1,1-dimethyl-ethyl)carbonylaminomethyl-benzamide

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Technology Process of N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2,6-dichloro-3-(2,2,2-trifluoro-1,1-dimethyl-ethyl)carbonylaminomethyl-benzamide

There total 4 articles about N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2,6-dichloro-3-(2,2,2-trifluoro-1,1-dimethyl-ethyl)carbonylaminomethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 889940-13-0
3,3,3-trifluoro-2,2-dimethylpropanoic acid

: 1294496-92-6
N-[4-(2,2-Difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2,6-dichloro-3-(aminomethyl)-benzamide

: 1294494-84-0
N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2,6-dichloro-3-(2,2,2-trifluoro-1,1-dimethyl-ethyl)carbonylaminomethyl-benzamide

Guidance literature:: 3,3,3-trifluoro-2,2-dimethylpropanoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

N-[4-(2,2-Difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2,6-dichloro-3-(aminomethyl)-benzamide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 50-30-6
2,6-dichlorobenzoic acid

: 1294494-84-0
N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2,6-dichloro-3-(2,2,2-trifluoro-1,1-dimethyl-ethyl)carbonylaminomethyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 20 °C

2.1: sodium hydroxide; water / methanol / 4 h / 20 °C

3.1: triethylamine / 1,4-dioxane / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4.2: 0.5 h / 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.33 h / 20 °C

5.2: 0.5 h / 20 °C

With sulfuric acid; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1294497-44-1
3-(trifluoromethylcarbonylamino-methyl)-2,6-dichloro-benzoic acid

: 1294494-84-0
N-[4-(2,2-difluoroethyl)oxy-3-(4-bromophenyl)aminocarbonyl-phenyl]-2,6-dichloro-3-(2,2,2-trifluoro-1,1-dimethyl-ethyl)carbonylaminomethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / methanol / 4 h / 20 °C

2.1: triethylamine / 1,4-dioxane / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3.2: 0.5 h / 20 °C

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.33 h / 20 °C

4.2: 0.5 h / 20 °C

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;