3-(1H-benzimidazol-2-yl)-4-(3-methylphenylamino)butanoic acid

Base Information

• Chemical Name: 3-(1H-benzimidazol-2-yl)-4-(3-methylphenylamino)butanoic acid
• CAS No.: 1423225-65-3
• Molecular Formula: C₁₈H₁₉N₃O₂
• Molecular Weight: 309.368
• Mol file: 1423225-65-3.mol

Synonyms:3-(1H-benzimidazol-2-yl)-4-(3-methylphenylamino)butanoic acid

Chemical Property of 3-(1H-benzimidazol-2-yl)-4-(3-methylphenylamino)butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1H-benzimidazol-2-yl)-4-(3-methylphenylamino)butanoic acid

There total 1 articles about 3-(1H-benzimidazol-2-yl)-4-(3-methylphenylamino)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-(1H-benzimidazol-2-yl)-1-(3-methylphenyl)pyrrolidin-2-one (573931-42-7) → 3-(1H-benzimidazol-2-yl)-4-(3-methylphenylamino)butanoic acid (1423225-65-3)

Guidance literature:

4-(1H-benzimidazol-2-yl)-1-(3-methylphenyl)pyrrolidin-2-one; With sodium hydroxide; for 4h; Reflux;

With acetic acid; In water; pH=6;

DOI:10.1007/s11164-013-1067-6

Reference yield: 94.0%

3-(1H-benzimidazol-2-yl)-4-(3-methylphenylamino)butanoic acid (1423225-65-3) → 4-(1H-benzimidazol-2-yl)-1-(3-methylphenyl)pyrrolidin-2-one (573931-42-7)

Guidance literature:

3-(1H-benzimidazol-2-yl)-4-(3-methylphenylamino)butanoic acid; With hydrogenchloride; In water; for 0.5h; Reflux;

With ammonium hydroxide; pH=8;

DOI:10.1007/s11164-013-1067-6

Reference yield:

3-(1H-benzimidazol-2-yl)-4-(3-methylphenylamino)butanoic acid (1423225-65-3) → 2-{2-[1-(3-methylphenyl)-5-oxo-3-pyrrolidinyl]-1H-benzimidazol-1-yl}-N’-(1-methylpropylidene)acetohydrazide (1423225-83-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 0.5 h / Reflux

1.2: pH 8

2.1: potassium carbonate; potassium hydroxide; tetra-(n-butyl)ammonium iodide / toluene / 0.17 h

2.2: 5 h / Reflux

3.1: hydrazine hydrate / isopropyl alcohol / 2 h / Reflux

4.1: 7 h / Reflux

With hydrogenchloride; hydrazine hydrate; tetra-(n-butyl)ammonium iodide; potassium carbonate; potassium hydroxide; In water; isopropyl alcohol; toluene;

DOI:10.1007/s11164-013-1067-6

upstream raw materials:

4-(1H-benzimidazol-2-yl)-1-(3-methylphenyl)pyrrolidin-2-one

Downstream raw materials:

4-(1H-benzimidazol-2-yl)-1-(3-methylphenyl)pyrrolidin-2-one

2-{2-[1-(3-methylphenyl)-5-oxo-3-pyrrolidinyl]-1H-benzimidazol-1-yl}-N’-(1-methylpropylidene)acetohydrazide

4-{1-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-2-oxoethyl]-1H-benzimidazol-2-yl}-1-(3-methylphenyl)-2-pyrrolidinone

N-(2,5-dimethyl-1H-pyrrol-1-yl)-2-{2-[1-(3-methylphenyl)-5-oxo-3-pyrrolidinyl]-1H-benzimidazol-1-yl}acetamide