<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane

Base Information

• Chemical Name: <4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane
• CAS No.: 148932-53-0
• Molecular Formula: C₂₁H₃₈N₆O₄S
• Molecular Weight: 470.637
• Mol file: 148932-53-0.mol

Synonyms:<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane

Chemical Property of <4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane

There total 2 articles about <4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-aminobutyl)-4-methoxybenzenesulfonamide hydrochloride → <4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane (148932-53-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 36 percent / aq. NaOH / 1,2-dichloro-ethane / 1.) -10 deg C, 1 h, 2.) RT, overnight

2: 1.) Mo(CO)6, 2.) K₂CO₃, 3.) 10percent aq. HCl, air

With hydrogenchloride; sodium hydroxide; air; hexacarbonyl molybdenum; potassium carbonate; In 1,2-dichloro-ethane;

Reference yield:

N-(4-bromoacetamidobutyl)-4-methoxybenzenesulfonamide (148932-52-9) + 1,4,7,10-tetraazacyclododecan (294-90-6) → <4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane (148932-53-0)

Guidance literature:

With hydrogenchloride; air; hexacarbonyl molybdenum; potassium carbonate; Yield given. Multistep reaction;

Reference yield: 82.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + methyldiethoxyphosphine (15715-41-0) + <4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane (148932-53-0) → triethyl 10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane-1,4,7-triyltrimethylenetri(methylphosphinate) (148932-59-6)

Guidance literature:

With 4 A molecular sieve; In tetrahydrofuran; at 100 ℃; for 18h;

upstream raw materials:

N-(4-bromoacetamidobutyl)-4-methoxybenzenesulfonamide

1,4,7,10-tetraazacyclododecan

Downstream raw materials:

triethyl 10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane-1,4,7-triyltrimethylenetri(methylphosphinate)

triethyl 10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane-1,4,7-triyltrimethylenetri(butylphosphinate)

triethyl 10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7,10-tetraazacyclododecane-1,4,7-triyltrimethylenetri(benzylphosphinate)

triethyl 10-<4-(4-methoxyphenylsulfonamido)butylcarbamoylmethyl>-1,4,7-tetraazacyclododecane-1,4,7-triyltriacetate