1-<3,5-di-O-(tert-butyldiphenylsilyl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>-5-formyluracil

Base Information

Chemical Name:1-<3,5-di-O-(tert-butyldiphenylsilyl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>-5-formyluracil
CAS No.:114652-75-4
Molecular Formula:C₄₂H₄₇FN₂O₆Si₂
Molecular Weight:751.014
Hs Code.:

Synonyms:1-<3,5-di-O-(tert-butyldiphenylsilyl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>-5-formyluracil

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Chemical Property of 1-<3,5-di-O-(tert-butyldiphenylsilyl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>-5-formyluracil

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Technology Process of 1-<3,5-di-O-(tert-butyldiphenylsilyl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>-5-formyluracil

There total 5 articles about 1-<3,5-di-O-(tert-butyldiphenylsilyl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>-5-formyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 114652-74-3
1-<3,5-di-O-(tert-butyldiphenylsilyl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>-α-hydroxythymine

: 114652-75-4
1-<3,5-di-O-(tert-butyldiphenylsilyl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>-5-formyluracil

Guidance literature:: With manganese(IV) oxide; In toluene; for 5h; Heating;
DOI:10.1021/jm00403a026

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 114652-75-4
1-<3,5-di-O-(tert-butyldiphenylsilyl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>-5-formyluracil

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / imidazole / dimethylformamide / Ambient temperature

2: NBS / CCl₄ / 2 h / Heating; Irradiation

3: 46 percent / aq. NaHCO₃ / tetrahydrofuran / Ambient temperature

4: 70 percent / MnO₂ / toluene / 5 h / Heating

With 1H-imidazole; manganese(IV) oxide; N-Bromosuccinimide; sodium hydrogencarbonate; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00403a026

Reference yield:

: 114652-73-2
1-<3,5-di-O-(tert-butyldiphenylsilyl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>thymine

: 114652-75-4
1-<3,5-di-O-(tert-butyldiphenylsilyl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>-5-formyluracil

Guidance literature:: Multi-step reaction with 3 steps

1: NBS / CCl₄ / 2 h / Heating; Irradiation

2: 46 percent / aq. NaHCO₃ / tetrahydrofuran / Ambient temperature

3: 70 percent / MnO₂ / toluene / 5 h / Heating

With manganese(IV) oxide; N-Bromosuccinimide; sodium hydrogencarbonate; In tetrahydrofuran; tetrachloromethane; toluene;
DOI:10.1021/jm00403a026