(+/-)-1-(3-phenylsulfinylpropyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)imidazole

Base Information

Chemical Name:(+/-)-1-(3-phenylsulfinylpropyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)imidazole
CAS No.:165806-62-2
Molecular Formula:C₂₃H₂₀FN₃OS
Molecular Weight:405.496
Hs Code.:

Synonyms:(+/-)-1-(3-phenylsulfinylpropyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)imidazole

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Chemical Property of (+/-)-1-(3-phenylsulfinylpropyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)imidazole

Chemical Property:

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Technology Process of (+/-)-1-(3-phenylsulfinylpropyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)imidazole

There total 7 articles about (+/-)-1-(3-phenylsulfinylpropyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 165806-60-0
1-[3-(Phenylthio)propyl]-4-(4-fluorophenyl)-5-(4-pyridinyl)imidazole

: 165806-62-2
(+/-)-1-(3-phenylsulfinylpropyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)imidazole

Guidance literature:: With dipotassium peroxodisulfate; acetic acid; In water; for 16h;
DOI:10.1021/jm960415o

Reference yield:

: 872-85-5
pyridine-4-carbaldehyde

: 165806-62-2
(+/-)-1-(3-phenylsulfinylpropyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / K₂CO₃ / H₂O; CH₂Cl₂ / 0.67 h

2: 38 percent / 1,5,7-triazabicyclo<4.4.0>dec-5-ene / CH₂Cl₂ / 16 h / 5 °C

3: dimethylformamide / 2 h / 50 °C

4: K₂S₂O₈, acetic acid / H₂O / 16 h

With dipotassium peroxodisulfate; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; potassium carbonate; acetic acid; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm960415o

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 165806-62-2
(+/-)-1-(3-phenylsulfinylpropyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / toluene / 18 h / Heating

2: 38 percent / 1,5,7-triazabicyclo<4.4.0>dec-5-ene / CH₂Cl₂ / 16 h / 5 °C

3: dimethylformamide / 2 h / 50 °C

4: K₂S₂O₈, acetic acid / H₂O / 16 h

With dipotassium peroxodisulfate; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; acetic acid; In dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm960415o