(S)-Hydroxy-phenyl-acetic acid (1R,2S,3R,4S)-1,7,7-trimethyl-3-(toluene-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl ester

Base Information

• Chemical Name: (S)-Hydroxy-phenyl-acetic acid (1R,2S,3R,4S)-1,7,7-trimethyl-3-(toluene-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl ester
• CAS No.: 146311-08-2
• Molecular Formula: C₂₅H₃₁NO₅S
• Molecular Weight: 457.591

Synonyms:(S)-Hydroxy-phenyl-acetic acid (1R,2S,3R,4S)-1,7,7-trimethyl-3-(toluene-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl ester

Chemical Property of (S)-Hydroxy-phenyl-acetic acid (1R,2S,3R,4S)-1,7,7-trimethyl-3-(toluene-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of (S)-Hydroxy-phenyl-acetic acid (1R,2S,3R,4S)-1,7,7-trimethyl-3-(toluene-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl ester

There total 4 articles about (S)-Hydroxy-phenyl-acetic acid (1R,2S,3R,4S)-1,7,7-trimethyl-3-(toluene-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylglyoxylyl chloride (25726-04-9) → (S)-Hydroxy-phenyl-acetic acid (1R,2S,3R,4S)-1,7,7-trimethyl-3-(toluene-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl ester (146311-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / Ambient temperature

2: LiAlH(OCEt₃)3 / tetrahydrofuran / 1 h / 0 °C

With pyridine; LiAlH(OCEt₃)3; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00057a004

Reference yield:

(2S)-3-exo-aminoisoborneol (41719-73-7) → (S)-Hydroxy-phenyl-acetic acid (1R,2S,3R,4S)-1,7,7-trimethyl-3-(toluene-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl ester (146311-08-2)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N, (N,N-dimethylamino)pyridine (DMAP) / CH₂Cl₂ / Ambient temperature

2: pyridine / CH₂Cl₂ / Ambient temperature

3: LiAlH(OCEt₃)3 / tetrahydrofuran / 1 h / 0 °C

With pyridine; dmap; LiAlH(OCEt₃)3; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00057a004

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → (S)-Hydroxy-phenyl-acetic acid (1R,2S,3R,4S)-1,7,7-trimethyl-3-(toluene-4-sulfonylamino)-bicyclo[2.2.1]hept-2-yl ester (146311-08-2)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N, (N,N-dimethylamino)pyridine (DMAP) / CH₂Cl₂ / Ambient temperature

2: pyridine / CH₂Cl₂ / Ambient temperature

3: LiAlH(OCEt₃)3 / tetrahydrofuran / 1 h / 0 °C

With pyridine; dmap; LiAlH(OCEt₃)3; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00057a004

upstream raw materials:

phenylglyoxylyl chloride

(2S)-3-exo-aminoisoborneol

p-toluenesulfonyl chloride

(1R,2S,3R,4S)-3-TsNH-1,7,7-(CH₃)3-bicyclo[2.2.1]heptan-2-ol

Downstream raw materials:

(S)-Mandelic acid

(R)-Mandelic Acid

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