8-Chloro-1-(1-chloro-ethyl)-6-(2-chloro-phenyl)-4H-2,3,5,10b-tetraaza-benzo[e]azulene

Base Information

• Chemical Name: 8-Chloro-1-(1-chloro-ethyl)-6-(2-chloro-phenyl)-4H-2,3,5,10b-tetraaza-benzo[e]azulene
• CAS No.: 72874-39-6
• Molecular Formula: C₁₈H₁₃Cl₃N₄
• Molecular Weight: 391.687

Synonyms:8-Chloro-1-(1-chloro-ethyl)-6-(2-chloro-phenyl)-4H-2,3,5,10b-tetraaza-benzo[e]azulene

Chemical Property of 8-Chloro-1-(1-chloro-ethyl)-6-(2-chloro-phenyl)-4H-2,3,5,10b-tetraaza-benzo[e]azulene

Chemical Property:

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Technology Process of 8-Chloro-1-(1-chloro-ethyl)-6-(2-chloro-phenyl)-4H-2,3,5,10b-tetraaza-benzo[e]azulene

There total 2 articles about 8-Chloro-1-(1-chloro-ethyl)-6-(2-chloro-phenyl)-4H-2,3,5,10b-tetraaza-benzo[e]azulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chloro-propionic acid N'-[7-chloro-5-(2-chloro-phenyl)-3H-benzo[e][1,4]diazepin-2-yl]-hydrazide → 8-Chloro-1-(1-chloro-ethyl)-6-(2-chloro-phenyl)-4H-2,3,5,10b-tetraaza-benzo[e]azulene (72874-39-6)

Guidance literature:

In acetic acid; for 0.333333h; Yield given; Heating;

DOI:10.1021/jm00178a009

Reference yield:

7-chloro-5-(o-chlorophenyl)-2-hydrazino-3H-1,4-benzodiazepine (40070-48-2,112393-63-2) → 8-Chloro-1-(1-chloro-ethyl)-6-(2-chloro-phenyl)-4H-2,3,5,10b-tetraaza-benzo[e]azulene (72874-39-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 1.58 h / 0 - 20 °C

2: acetic acid / 0.33 h / Heating

In tetrahydrofuran; acetic acid;

DOI:10.1021/jm00178a009

Reference yield: 25.0%

8-Chloro-1-(1-chloro-ethyl)-6-(2-chloro-phenyl)-4H-2,3,5,10b-tetraaza-benzo[e]azulene (72874-39-6) → 1-[8-Chloro-6-(2-chloro-phenyl)-4H-2,3,5,10b-tetraaza-benzo[e]azulen-1-yl]-ethylamine (72874-43-2)

Guidance literature:

With ammonia; potassium iodide; In tetrahydrofuran; methanol; at 25 ℃; for 336h;

DOI:10.1021/jm00178a009

upstream raw materials:

7-chloro-5-(o-chlorophenyl)-2-hydrazino-3H-1,4-benzodiazepine

Downstream raw materials:

1-[8-Chloro-6-(2-chloro-phenyl)-4H-2,3,5,10b-tetraaza-benzo[e]azulen-1-yl]-ethylamine

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