Technology Process of Acetic acid (2R,3S,5R)-2-{[6-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2H-benzo[g]pteridin-10-yl)-hexyloxy]-hydroxy-phosphoryloxymethyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
There total 8 articles about Acetic acid (2R,3S,5R)-2-{[6-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2H-benzo[g]pteridin-10-yl)-hexyloxy]-hydroxy-phosphoryloxymethyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 98 percent / Et3N / 5 h / 110 °C
2: 63 percent / H2O; dioxane / 15 h / Heating
3: 94 percent / NaNO3 / acetic acid / 3 h / Ambient temperature
4: 90 percent / aq. dithiothreitol / ethanol / 0.33 h / Heating
5: 90 percent / H3PO3, 2,4,6-triisopropylbenzenesylfonyl chloride / pyridine / 15 h / Ambient temperature
6: 75 percent / 1-adamantanecarboxylic acid chloride / pyridine / 24 h
7: I2, Et3N / pyridine; tetrahydrofuran / 5 h
With
sodium nitrate; phosphonic Acid; 2,4,6-triisopropylphenylsulfonyl chloride; iodine; 1-Adamantanecarbonyl chloride; triethylamine; diothiothreitol;
In
tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; water; acetic acid;
DOI:10.1021/jo962361w
- Guidance literature:
-
With
iodine; triethylamine;
In
tetrahydrofuran; pyridine;
for 5h;
DOI:10.1021/jo962361w
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 98 percent / Et3N / 5 h / 110 °C
2: 63 percent / H2O; dioxane / 15 h / Heating
3: 94 percent / NaNO3 / acetic acid / 3 h / Ambient temperature
4: 90 percent / aq. dithiothreitol / ethanol / 0.33 h / Heating
5: 90 percent / H3PO3, 2,4,6-triisopropylbenzenesylfonyl chloride / pyridine / 15 h / Ambient temperature
6: 75 percent / 1-adamantanecarboxylic acid chloride / pyridine / 24 h
7: I2, Et3N / pyridine; tetrahydrofuran / 5 h
With
sodium nitrate; phosphonic Acid; 2,4,6-triisopropylphenylsulfonyl chloride; iodine; 1-Adamantanecarbonyl chloride; triethylamine; diothiothreitol;
In
tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; water; acetic acid;
DOI:10.1021/jo962361w
