tert-butyl (6Z,10R)-6-amino-10-(3-cyclohexylpropyl)-9-oxo-8-oxa-2-thia-3,7-diazadodec-6-en-12-oate 2,2-dioxide

Base Information

Chemical Name:tert-butyl (6Z,10R)-6-amino-10-(3-cyclohexylpropyl)-9-oxo-8-oxa-2-thia-3,7-diazadodec-6-en-12-oate 2,2-dioxide
CAS No.:944731-39-9
Molecular Formula:C₂₁H₃₉N₃O₆S
Molecular Weight:461.623
Hs Code.:

Synonyms:tert-butyl (6Z,10R)-6-amino-10-(3-cyclohexylpropyl)-9-oxo-8-oxa-2-thia-3,7-diazadodec-6-en-12-oate 2,2-dioxide

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Chemical Property of tert-butyl (6Z,10R)-6-amino-10-(3-cyclohexylpropyl)-9-oxo-8-oxa-2-thia-3,7-diazadodec-6-en-12-oate 2,2-dioxide

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Technology Process of tert-butyl (6Z,10R)-6-amino-10-(3-cyclohexylpropyl)-9-oxo-8-oxa-2-thia-3,7-diazadodec-6-en-12-oate 2,2-dioxide

There total 1 articles about tert-butyl (6Z,10R)-6-amino-10-(3-cyclohexylpropyl)-9-oxo-8-oxa-2-thia-3,7-diazadodec-6-en-12-oate 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 439287-89-5,944731-38-8
(1Z)-N'-hydroxy-3-[(methylsulfonyl)amino]propanimidamide

: 343251-07-0
(2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-cyclohexylpentanoic acid

: 944731-39-9
tert-butyl (6Z,10R)-6-amino-10-(3-cyclohexylpropyl)-9-oxo-8-oxa-2-thia-3,7-diazadodec-6-en-12-oate 2,2-dioxide

Guidance literature:: With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃;
DOI:10.1021/jm061010z

Reference yield: 83.0%

: 944731-39-9
tert-butyl (6Z,10R)-6-amino-10-(3-cyclohexylpropyl)-9-oxo-8-oxa-2-thia-3,7-diazadodec-6-en-12-oate 2,2-dioxide

: 438630-69-4
tert-butyl (3R)-6-cyclohexyl-3-(3-{2-[(methylsulfonyl)amino]ethyl}-1,2,4-oxadiazol-5-yl)hexanoate

: 438630-55-8
tert-butyl (3R)-6-cyclohexyl-3-(3-{[(methylsulfonyl)amino]methyl}-1,2,4-oxadiazol-5-yl)hexanoate

Guidance literature:: In ethyl acetate;

Reference yield:

: 944731-39-9
tert-butyl (6Z,10R)-6-amino-10-(3-cyclohexylpropyl)-9-oxo-8-oxa-2-thia-3,7-diazadodec-6-en-12-oate 2,2-dioxide

: 438629-34-6
(3R)-6-cyclohexyl-3-(3-{2-[(methylsulfonyl)amino]ethyl}-1,2,4-oxadiazol-5-yl)hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 910 mg / xylene / Heating

2: 370 mg / trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With trifluoroacetic acid; In dichloromethane; xylene;
DOI:10.1021/jm061010z