(7R)-7-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane

Base Information

• Chemical Name: (7R)-7-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane
• CAS No.: 1030377-29-7
• Molecular Formula: C₁₅H₁₉N₅O
• Molecular Weight: 285.349
• Mol file: 1030377-29-7.mol

Synonyms:(7R)-7-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane

Chemical Property of (7R)-7-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (7R)-7-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane

There total 1 articles about (7R)-7-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl (5R)-5-methyl-4-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane-1-carboxylate (1030377-28-6) → (7R)-7-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane (1030377-29-7)

Guidance literature:

With hydrogen; palladium(II) hydroxide/carbon; In ethyl acetate;

Reference yield: 73.0%

(7R)-7-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane (1030377-29-7) + 2,4,5-trichloropyrimidine (5750-76-5) → C19H19Cl2N7O

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 - 23 ℃; for 18h; regioselective reaction;

DOI:10.1016/j.bmcl.2014.12.081

Reference yield: 56.0%

(7R)-7-methyl-1-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane (1030377-29-7) + 2,4-dichloro-5-trifluoromethylpyrimidine (3932-97-6) → C20H19ClF3N7O + C20H19ClF3N7O

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 18h; regioselective reaction;

DOI:10.1016/j.bmcl.2014.12.081

upstream raw materials:

benzyl (5R)-5-methyl-4-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepane-1-carboxylate

Downstream raw materials:

6-fluoro-2-{(5R)-5-methyl-4-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl}quinazoline

6,7-difluoro-2-{(5R)-5-methyl-4-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl}quinoxaline

5-methyl-2-{(5R)-5-methyl-4-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl}thieno[2,3-d]pyrimidine

2-{(5R)-5-methyl-4-[2-(2H-1,2,3-triazol-2-yl)benzoyl]-1,4-diazepan-1-yl}quinazoline