Technology Process of 3'-isocyano-2',3'-dideoxyuridine
There total 7 articles about 3'-isocyano-2',3'-dideoxyuridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
for 0.333333h;
DOI:10.1021/jm00164a059
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 89 percent / imidazole / dimethylformamide / 1.) -10 deg C, 1 h, 2.) room temp.
2: 88 percent / triphenylphosphane (TPP), diethyl azodicarboxylate (DEAD) / toluene / 0.5 h / 80 °C
3: 55 percent / NaN3 / dimethylformamide; H2O / 11 h / Heating
4: triphenylphosphane (TPP) / toluene / 0 °C
5: toluene / 4 h / 60 °C
6: 47 percent / POCl3, i-Pr2NH / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) room temp.
7: 88 percent / 0.5 M tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 0.33 h
With
1H-imidazole; sodium azide; tetrabutyl ammonium fluoride; diisopropylamine; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00164a059
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 55 percent / NaN3 / dimethylformamide; H2O / 11 h / Heating
2: triphenylphosphane (TPP) / toluene / 0 °C
3: toluene / 4 h / 60 °C
4: 47 percent / POCl3, i-Pr2NH / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) room temp.
5: 88 percent / 0.5 M tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 0.33 h
With
sodium azide; tetrabutyl ammonium fluoride; diisopropylamine; triphenylphosphine; trichlorophosphate;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00164a059
