(E)-diethyl 1-benzyl-3-butylidene-5-oxopyrrolidine-2,2-dicarboxylate

Base Information

• Chemical Name: (E)-diethyl 1-benzyl-3-butylidene-5-oxopyrrolidine-2,2-dicarboxylate
• CAS No.: 1351364-82-3
• Molecular Formula: C₂₁H₂₇NO₅
• Molecular Weight: 373.449
• Mol file: 1351364-82-3.mol

Synonyms:(E)-diethyl 1-benzyl-3-butylidene-5-oxopyrrolidine-2,2-dicarboxylate

Chemical Property of (E)-diethyl 1-benzyl-3-butylidene-5-oxopyrrolidine-2,2-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-diethyl 1-benzyl-3-butylidene-5-oxopyrrolidine-2,2-dicarboxylate

There total 4 articles about (E)-diethyl 1-benzyl-3-butylidene-5-oxopyrrolidine-2,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

diethyl 2-(N-(benzyl)hep-3-ynamido)malonate (1351364-64-1) → (E)-diethyl 1-benzyl-3-butylidene-5-oxopyrrolidine-2,2-dicarboxylate (1351364-82-3)

Guidance literature:

With zinc(II) chloride; In 1,2-dichloro-ethane; at 100 ℃; for 15h; Sealed tube;

DOI:10.1002/adsc.201100401

Reference yield:

diethyl 2-(N-(benzyl)hep-3-ynamido)malonate (1351364-64-1) → (E)-diethyl 1-benzyl-3-butylidene-5-oxopyrrolidine-2,2-dicarboxylate (1351364-82-3) + diethyl 1-benzyl-5-oxo-3Z-butylidenepyrrolidine-2,2-dicarboxylate

Guidance literature:

With manganese(II) acetate dihydrate; In ethanol; at 20 ℃; for 2h; optical yield given as %de; diastereoselective reaction;

DOI:10.1039/c2cc32382f

Reference yield:

C7H9ClO → (E)-diethyl 1-benzyl-3-butylidene-5-oxopyrrolidine-2,2-dicarboxylate (1351364-82-3) + diethyl 1-benzyl-5-oxo-3Z-butylidenepyrrolidine-2,2-dicarboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane / 0.5 h / 20 °C

2: manganese(II) acetate dihydrate / ethanol / 2 h / 20 °C

With manganese(II) acetate dihydrate; sodium hydrogencarbonate; In ethanol; dichloromethane;

DOI:10.1039/c2cc32382f

upstream raw materials:

diethyl 2-(N-(benzyl)hep-3-ynamido)malonate

hept-3-ynoic acid