2',3'-Dideoxy-2',3'-methanocytidine

Base Information

Chemical Name:2',3'-Dideoxy-2',3'-methanocytidine
CAS No.:131347-68-7
Molecular Formula:C₁₀H₁₃N₃O₃
Molecular Weight:223.232
Hs Code.:
DSSTox Substance ID:DTXSID40927166

Synonyms:2',3'-dideoxy-2',3'-alpha-methanocytidine;2',3'-dideoxy-2',3'-methanocytidine;2,3-DDMCT

Suppliers and Price of 2',3'-Dideoxy-2',3'-methanocytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2',3'-Dideoxy-2',3'-methanocytidine

Chemical Property:

Boiling Point:436.4°Cat760mmHg
Flash Point:217.7°C
PSA：91.36000
Density:1.83g/cm³
LogP:-0.30630
XLogP3:-1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:223.09569129
Heavy Atom Count:16
Complexity:393

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2C1C(OC2CO)N3C=CC(=NC3=O)N
Isomeric SMILES:C1[C@H]2[C@@H]1C(OC2CO)N3C=CC(=NC3=O)N

Technology Process of 2',3'-Dideoxy-2',3'-methanocytidine

There total 7 articles about 2',3'-Dideoxy-2',3'-methanocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78508-96-0
(5S)-5-(hydroxymethyl)-5H-furan-2-one

: 131347-68-7
2',3'-Dideoxy-2',3'-α-methano-α-cytidine

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

2: 88 percent / CHCl₃; diethyl ether / 18 h / 0 °C

3: 94 percent / benzophenone / benzene; acetonitrile / 2 h / Irradiation

4: 1) disiamylborane, 2) aq. 27percent H₂O₂, 2 M NaOH / 1) THF, a) room temp., b) water, reflux, 30 min

5: 450 mg / pyridine, 4-dimethylaminopyridine / CHCl₃ / 72 h

6: 37 percent / EtAlCl₂ / toluene; CH₂Cl₂ / 0.67 h / Ambient temperature

7: 30 mg / methanolic ammonia / 24 h / Ambient temperature

With pyridine; dmap; sodium hydroxide; benzophenone; ammonia; dihydrogen peroxide; ethylaluminum dichloride; bis-(1,2-dimethylpropyl)borane; In diethyl ether; dichloromethane; chloroform; toluene; acetonitrile; benzene;
DOI:10.1016/0008-6215(90)80130-U

Reference yield:

: 96086-02-1
(5S)-5-(benzoyloxymethyl)-5H-furan-2-one

: 131347-68-7
2',3'-Dideoxy-2',3'-α-methano-α-cytidine

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / CHCl₃; diethyl ether / 18 h / 0 °C

2: 94 percent / benzophenone / benzene; acetonitrile / 2 h / Irradiation

3: 1) disiamylborane, 2) aq. 27percent H₂O₂, 2 M NaOH / 1) THF, a) room temp., b) water, reflux, 30 min

4: 450 mg / pyridine, 4-dimethylaminopyridine / CHCl₃ / 72 h

5: 37 percent / EtAlCl₂ / toluene; CH₂Cl₂ / 0.67 h / Ambient temperature

6: 30 mg / methanolic ammonia / 24 h / Ambient temperature

With pyridine; dmap; sodium hydroxide; benzophenone; ammonia; dihydrogen peroxide; ethylaluminum dichloride; bis-(1,2-dimethylpropyl)borane; In diethyl ether; dichloromethane; chloroform; toluene; acetonitrile; benzene;
DOI:10.1016/0008-6215(90)80130-U

Reference yield:

: Benzoic acid (1S,2S,5R)-4-hydroxy-3-oxa-bicyclo[3.1.0]hex-2-ylmethyl ester

: 131347-68-7
2',3'-Dideoxy-2',3'-α-methano-α-cytidine

Guidance literature:: Multi-step reaction with 3 steps

1: 450 mg / pyridine, 4-dimethylaminopyridine / CHCl₃ / 72 h

2: 37 percent / EtAlCl₂ / toluene; CH₂Cl₂ / 0.67 h / Ambient temperature

3: 30 mg / methanolic ammonia / 24 h / Ambient temperature

With pyridine; dmap; ammonia; ethylaluminum dichloride; In dichloromethane; chloroform; toluene;
DOI:10.1016/0008-6215(90)80130-U